PMID: 8610222Jan 1, 1995Paper

Raised IgA rheumatoid factor (RF) but not IgM RF or IgG RF is associated with extra-articular manifestations in rheumatoid arthritis

Scandinavian Journal of Rheumatology
T JónssonH Valdimarsson

Abstract

In rheumatoid arthritis (RA) seropositivity has been associated with poor prognosis including bone erosions and extra-articular manifestations. However, findings have been conflicting on the association between individual rheumatoid factor (RF) isotypes and extra-articular manifestations. In this study the occurrence of extra-articular manifestations was examined in the context of the RF isotype patterns rather than individual RF isotypes. IgM, IgG and IgA RF was measured by ELISA in 74 patients with RA and the findings correlated with the presence or absence of extra-articular manifestations. Of the IgA RF positive patients 80% had one or more extra-articular manifestations. In contrast, only 21% of patients with raised IgM and/or IgG RF but normal IgA RF had some extra-articular manifestations and 27% of the seronegative patients. It is concluded that the previously reported association between raised RF and extra-articular manifestations in RA can largely be attributed to the IgA RF isotype.

References

Jan 1, 1992·Rheumatology International·T Jónsson, H Valdimarsson
Jul 1, 1992·Annals of the Rheumatic Diseases·T JónssonH Valdimarsson
Jan 1, 1986·Rheumatology International·T JonssonH Valdimarsson
Jan 1, 1987·Annals of the Rheumatic Diseases·M Gioud-PaquetJ C Monier
Jan 1, 1985·Rheumatology International·M L WestedtJ Lindeman
Oct 1, 1984·Annals of the Rheumatic Diseases·I TeitssonH Valdimarsson
May 1, 1982·Arthritis and Rheumatism·G S AlarcónB O Barger

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Citations

Jun 22, 2012·Clinical Reviews in Allergy & Immunology·Rita A MouraJoão E Fonseca
Nov 21, 2009·QJM : Monthly Journal of the Association of Physicians·Y W Song, E H Kang
May 15, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·A Griesmacher, P Peichl
May 28, 2004·Scandinavian Journal of Rheumatology·C Turesson, L T H Jacobsson
Sep 18, 2007·Best Practice & Research. Clinical Rheumatology·Adam Young, Gouri Koduri
Jul 12, 2008·Orvosi hetilap·György BernschererZsolt Tarján
Oct 27, 2015·Immunological Reviews·Esil AleydMarjolein van Egmond
Oct 23, 2008·Scandinavian Journal of Rheumatology·E PeenH-J Haga
Nov 21, 2000·Rheumatology·B MasdottirH Valdimarsson
Dec 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esil AleydMarjolein van Egmond
Jan 19, 2019·Advances in Rheumatology·Sara de Brito RochaLuis Eduardo Coelho Andrade
Sep 16, 2017·Terapevticheskiĭ arkhiv·N V ChebotarevaS V Gulyaev
Apr 16, 2019·Frontiers in Immunology·Annelot Breedveld, Marjolein van Egmond
Nov 28, 2019·Mediators of Inflammation·Qinghua FangKutty Selva Nandakumar
Jan 16, 2021·ImmunoTargets and Therapy·Melissa Maria Johanna van Gool, Marjolein van Egmond

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