PMID: 12780693Jun 5, 2003Paper

Raised serum levels of interleukin-18 is associated with disease progression and may contribute to virological treatment failure in HIV-1-infected patients

Clinical and Experimental Immunology
E StylianouS S Frøland

Abstract

To gain further insight into the possible role of interleukin (IL)-18 in HIV-1 infection we examined serum levels of IL-18 in various clinical and immunological stages of HIV-1 infection during cross-sectional (n = 41) and longitudinal testing (n = 20) and during HAART (n = 21, 24 months follow-up). Our main findings were that HIV-1-infected patients had significantly raised IL-18 levels comparing healthy controls, particularly in those with advanced disease, that while HAART induced a marked decline in IL-18, virological treatment failure was associated with persistently raised IL-18 levels during such therapy and that our in vitro experiments showed an IL-18-mediated up-regulation of the HIV-1 coreceptor CXCR4 and the pro-apoptotic mediator TRAIL in PBMC from HIV-1-infected patients receiving HAART. HIV-1 infection appears to be characterized by persistently raised IL-18 levels and during HAART, such a pattern was associated with virological treatment failure, possibly contributing to immunodeficiency and HIV-1 replication in these patients.

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Citations

May 3, 2005·Journal of Theoretical Biology·Jacob P Couturier, Robert S Root-Bernstein
Jul 27, 2007·Retrovirology·Juan Lama, Vicente Planelles
Dec 1, 2011·Balkan Journal of Medical Genetics : BJMG·Rc SobtiA Wanchu
Jun 30, 2012·Cytokine & Growth Factor Reviews·Claire VandergeetenNicolas Chomont
Mar 18, 2006·Clinical and Experimental Immunology·W SongJ Tang
Nov 24, 2004·Microbes and Infection·Alicja Wiercinska-DrapaloDanuta Prokopowicz
May 17, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C TorneroD Navarro
Dec 16, 2016·PLoS Pathogens·Jeroen SlaatsMihai G Netea
Apr 22, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jennifer H YearleyKeith G Mansfield
Apr 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Birgitte LindegaardBente Klarlund Pedersen
Aug 15, 2020·Journal of Cellular Physiology·Alessandra VecchiéAntonio Abbate
Dec 14, 2019·Molecular Immunology·Vinicius Nunes Cordeiro LealAlessandra Pontillo

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