PMID: 6407695Jul 2, 1983Paper

Raised serum urate concentration as risk factor for premature mortality in middle aged men: relation to death from cancer

British Medical Journal
B Petersson, E Trell

Abstract

Low serum cholesterol concentrations are associated with deaths from cancer. This association was found in a prospective study of middle aged men in Malmö and consideration of possible explanations for the lowering of serum cholesterol prompted an analysis of serum urate in relation to deaths from cancer. A total of 127 of the 7725 participants in the Malmö study had died since screening. A weakly positive but significant correlation between raised serum urate concentration and total mortality was found. This correlation was wholly explained by neoplastic deaths (p less than 0.01), while there were no associations with alcohol related deaths or with deaths from coronary heart disease. When the deaths from cancer were classified as "early" or "late"--that is, occurring less than or more than 2.5 years after the screening--the correlation between raised urate concentrations and cancer mortality was confined to the "early" deaths (p less than 0.001). Further studies are needed to substantiate the relation between raised serum urate concentrations and fatal neoplasia. Nevertheless, these findings weigh against recent suggestions that uric acid has an antioxidant protective effect against cancer.

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Citations

Aug 15, 1983·Klinische Wochenschrift·B Peterson, E Trell
Aug 1, 2007·Cancer Causes & Control : CCC·Alexander M StrasakUNKNOWN VHM&PP Study Group
Feb 2, 2013·Clinical and Translational Medicine·Mehdi A FiniRichard M Wright
Sep 1, 1984·The American Journal of Medicine·B PeterssonB Hood
Oct 1, 1996·Journal of Clinical Pharmacy and Therapeutics·S BurgazN Y Ozdamar
Jul 15, 2016·Nature Reviews. Rheumatology·Philip C RobinsonTony R Merriman
May 13, 1999·Journal of Clinical Pharmacy and Therapeutics·A BozkirM Torun
Aug 9, 2001·Journal of Clinical Pharmacy and Therapeutics·C AbiakaA Simbeye
Mar 24, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Frances Dovell, Paolo Boffetta
Jul 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·J JancarG Carter
Apr 22, 2017·Clinical Chemistry·Camilla J KobyleckiBørge G Nordestgaard
Dec 20, 2019·Immunological Reviews·Georgiana CabăuLeo A B Joosten
Jun 5, 2004·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Sun Ha JeeMiyong T Kim

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