Raising the bar for reproducible science at the U.S. Environmental Protection Agency Office of Research and Development

Toxicological Sciences : an Official Journal of the Society of Toxicology
Barbara Jane GeorgeCommunity of Practice for Statistics Guidance Documents Working Groups

Abstract

Considerable concern has been raised regarding research reproducibility both within and outside the scientific community. Several factors possibly contribute to a lack of reproducibility, including a failure to adequately employ statistical considerations during study design, bias in sample selection or subject recruitment, errors in developing data inclusion/exclusion criteria, and flawed statistical analysis. To address some of these issues, several publishers have developed checklists that authors must complete. Others have either enhanced statistical expertise on existing editorial boards, or formed distinct statistics editorial boards. Although the U.S. Environmental Protection Agency, Office of Research and Development, already has a strong Quality Assurance Program, an initiative was undertaken to further strengthen statistics consideration and other factors in study design and also to ensure these same factors are evaluated during the review and approval of study protocols. To raise awareness of the importance of statistical issues and provide a forum for robust discussion, a Community of Practice for Statistics was formed in January 2014. In addition, three working groups were established to develop a series of questio...Continue Reading

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Feb 25, 2021·Environmental Science & Technology·Barbara Jane GeorgeJane Ellen Simmons

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