Raloxifene promotes adipocyte differentiation of 3T3-L1 cells

European Journal of Pharmacology
Yuko MuraseHiroshi Mabuchi

Abstract

To explore the possibility that raloxifene might influence an adipocyte differentiation and lipogenesis, we studied the effects of raloxifene on the expression of adiponectin and other peroxisome proliferator-activated receptor gamma targeting genes using the 3T3-L1 adipocytes. With standard adipogenic inducers, we added raloxifene at various doses for the adipocyte differentiation. Higher doses of raloxifene facilitated lipid accumulation of the 3T3-L1 cells. We next examined the differentiating and differentiated adipocytes and found that raloxifene augmented mRNA levels of adiponectin, adipocyte-specific fatty acid binding protein, and lipoprotein lipase dose-dependently in both. These effects were opposite those of 17beta-estradiol treatment. These findings suggest that raloxifene promotes adipocyte differentiation, providing a novel insight into the treatment of postmenopausal metabolic syndrome with hypoadiponectinemia.

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Citations

Jun 7, 2008·Journal of Biomedical Science·Jin-Ying LuWei-Shiung Yang
Dec 1, 2011·Journal of Agricultural and Food Chemistry·Charles E WoodMatthew E Burow
May 15, 2007·Current Opinion in Lipidology·Cristina Lara-CastroW Timothy Garvey
Jul 8, 2014·Journal of Atherosclerosis and Thrombosis·Xiaolei ZhangJinchuan Yan
May 16, 2009·Prostaglandins & Other Lipid Mediators·Eric R Prossnitz, Matthias Barton
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Jan 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oyindamola Vivian OjulariJu-Ock Nam
Feb 12, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Xiaohui WuYuqiao Xu

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