Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity

British Journal of Cancer
C H KohneB Dörken

Abstract

Two patients with proven 5-fluorouracil (5-FU)-associated cardiotoxicity were treated with the specific thymidylate synthase inhibitor raltitrexed safely, without evidence of cardiotoxicity. Raltitrexed might be an alternative for patients with advanced colorectal cancer and 5-FU-associated cardiotoxicity. 5-FU cardiotoxicity is not due to the antineoplastic mechanisms via thymidilate synthase.

Citations

Apr 9, 2009·Anti-cancer Drugs·Jonathan R Dalzell, Leslie M Samuel
May 29, 2003·British Journal of Cancer·G CianciC Ficorella
Mar 25, 2009·Expert Opinion on Drug Safety·M Wasif SaifAnuj R Shah
Mar 25, 2006·Expert Opinion on Pharmacotherapy·Shousong CaoMarwan Fakih
May 24, 2011·Cancer Chemotherapy and Pharmacology·Søren Astrup Jensen, Jens Benn Sørensen
Nov 27, 2002·Cancer Investigation·Sanford KempinRobert Diasio
Mar 20, 2008·World Journal of Gastroenterology : WJG·Gerardo Rosati, Domenico Bilancia
Nov 28, 2013·Pharmaceuticals·Christina Leah B Kline, Wafik S El-Deiry
Jan 19, 2006·Cancer Chemotherapy and Pharmacology·Søren Astrup Jensen, Jens Benn Sørensen
Nov 1, 2005·Expert Opinion on Drug Safety·Gerardo Rosati
Dec 15, 2020·European Journal of Medicinal Chemistry·Fabiana PlesciaDemetrio Raffa
Dec 5, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D RansomT J Price
May 26, 2005·Il Farmaco·Ljubica Glavas-ObrovacBiserka Zinić
Sep 3, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Claire GalloisJulien Taieb

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