Raman spectroscopic study of DNA after photosensitive damage caused by hypocrellins A and B

Science in China. Series C, Life Sciences
Y XuH Zhang

Abstract

Laser Raman spectroscopy provided the direct evidence for microcosmic photodamage in space structure of DNA molecule. When photosensitive damage was made to space structure of calf thymus DNA by hypocrellins A and B. the Raman characteristic frequencies and the intensities of the bands assigned to various groups of the components of DNA (phosphate backbone dsoxyribose and four bases) changed at various degrees. There were not only the strsnd breakage, but also the breakage of some H-bonds and disruption of vertical base-base stacking interactions. The photosensitive damage of hypocrellin B on DNA was stronger than that of hypocrellin A on DNA.

References

Mar 1, 1978·Nucleic Acids Research·D C Goodwin, J Brahms
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Feb 1, 1992·International Journal of Radiation Biology·E H CaoL S Cheng
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Feb 1, 1997·Photochemistry and Photobiology·J B HudsonZ Diwu

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Citations

Oct 17, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhan-Sen HuangJun Chen
Aug 30, 2014·Environmental Science and Pollution Research International·Jun ChenSong-Hao Liu
Jun 27, 2018·Frontiers in Cellular and Infection Microbiology·Wentao LyuGuolong Zhang
Jun 24, 2019·Applied Microbiology and Biotechnology·Jie LiShuang Wang

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