Raman Spectroscopy Applied to the Noninvasive Detection of Monosodium Urate Crystal Deposits

Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
Declan J CurranMark R Towler

Abstract

An off-the-shelf Raman Spectrometer (RS) was used to noninvasively determine the presence of monosodium urate (MSU) crystals on the metatarsophalangeal joint (MTPJ) of a single gout sufferer. The spectrum sourced from the clinically diagnosed gout sufferer was compared to that sourced from an age-matched healthy subject scanned using the same protocol. Minimal signal processing was conducted on both spectra. Peaks characteristic of MSU crystals were evident on the spectrum sourced from the gout sufferer and not on the spectrum from the healthy control.

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Citations

Jan 3, 2019·Current Opinion in Rheumatology·Monica ZellJohn FitzGerald
Oct 28, 2019·Diagnostics·Srinivas PentyalaLawrence C Hurst

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Methods Mentioned

BETA
light microscopy

Software Mentioned

Snowy Range Peak [UNK]
XRA
GRAMS
DECT
Peak Software

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