Raman Spectroscopy for Inverted Papilloma: A Proof-of-Concept Study

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Marco A MascarellaMarc A Tewfik

Abstract

Inverted papillomas are tumors of the sinonasal tract with a propensity to recur. Raman spectroscopy can potentially identify inverted papillomas from other tissue based on biochemical signatures. A pilot study comparing Raman spectroscopy to histopathology for 3 types of sinonasal tissue was performed. Spectral data of biopsies from patients with normal sinonasal mucosa, chronic rhinosinusitis, and inverted papillomas are compared to histopathology using principal component analysis and linear discriminant analysis after data preprocessing. A total of 18 normal, 15 chronic rhinosinusitis, and 18 inverted papilloma specimens were evaluated. The model distinguished normal sinonasal mucosa, chronic rhinosinusitis, and inverted papilloma tissue with an overall accuracy of 90.2% (95% confidence interval, 0.86-0.94). In conclusion, Raman spectroscopy can distinguish inverted papilloma, normal sinonasal mucosa, and chronically rhinosinusitis tissue with acceptable accuracy.

References

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Aug 30, 2005·Lasers in Surgery and Medicine·David P LauHaishan Zeng
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Citations

Oct 1, 2020·Chemical Society Reviews·Nicole M Ralbovsky, Igor K Lednev
Nov 6, 2021·European Journal of Nuclear Medicine and Molecular Imaging·J VonkMjh Witjes

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

HRME
R Foundation for Statistical Computing
R
OPUS

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