Raman spectroscopy for tablet coating thickness quantification and coating characterization in the presence of strong fluorescent interference

Journal of Pharmaceutical and Biomedical Analysis
Saly Romero-TorresEdward R Grant

Abstract

We report a novel approach to the measurement of colored tablet coating thickness, which employs Raman spectroscopy with univariate and multivariate data analysis. Our results suggest that Raman sensing can serve as a viable non-invasive means to quantify tablet coating thickness in the presence of a fluorescent ingredient in the coating formulation (food colorant Alphazurine FG or D&C Blue No. 4). This study comparatively tests the advantage of several data transformation approaches, including mean centering, standard normal variate, and Savitzky-Golay smoothed second derivative as means of improving predictive models in the presence of fluorescence. By application of the partial least squares (PLS) calibration algorithm to establish optimum covariance between transformed spectral data and measured tablet coating thicknesses, we have been able to create predictive models with calibration errors as small as 4 microm for a training set that spans colored coating thicknesses from 50 to 151 microm.

References

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Jun 1, 2005·Journal of Pharmaceutical and Biomedical Analysis·Saly Romero-TorresEdward R Grant
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Citations

Feb 8, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Daniel MarklJohannes G Khinast
Sep 26, 2009·Drug Development and Industrial Pharmacy·Joshua MüllerPeter Kleinebudde
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