Ramelteon attenuates age-associated hypertension and weight gain in spontaneously hypertensive rats

Annals of the New York Academy of Sciences
Gregory F Oxenkrug, Paul Summergrad

Abstract

The neuroendocrine theory of aging suggests the common mechanisms of developmental (prereproductive) and aging (postreproductive) processes and identified a cluster of conditions (hypertension, obesity, dyslipidemia, type 2 diabetes, menopause, late onset depression, vascular cognitive impairment, impairment of immune defense, and some forms of cancer) as age-associated neuroendocrine disorders (AAND). Obesity, dyslipidemia, hypertension, and type 2 diabetes were later described as metabolic syndrome (MetS). Because melatonin attenuated development of MetS is age-dependent, that is, in young and old, but not in middle-aged rats, we studied the effect of the selective melatonin agonist, Ramelteon, on the two core symptoms of MetS/AAND: hypertension and body weight gain in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto male rats (WKY). SHR rats developed hypertension at the time of maximal weight gain that coincided with the onset of reproductive activity (8-10 weeks old). Chronic (but not acute) administration of Ramelteon (in drinking water, 8 mg/kg/day, from 4 to 12 weeks of age) attenuated age-associated increase of systolic blood pressure (tail-cuff method) by 45%, and age-associated body weight gain by 30%. ...Continue Reading

References

Dec 1, 1978·Metabolism: Clinical and Experimental·J B YoungL Landsberg
Dec 1, 1992·Neuroendocrinology·M ViswanathanJ M Saavedra
Jan 1, 1986·Journal of Neural Transmission·G F OxenkrugR L Commissaris
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·K KawashimaH Koike
Nov 1, 1967·Life Sciences·A Zanoboni, W Zanoboni-Muciaccia
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·K KawashimaS Spector
Mar 1, 1980·Canadian Journal of Physiology and Pharmacology·S C CunnaneD F Horrobin
Jan 1, 1997·Journal of Pineal Research·A CagnacciG B Melis
Jun 13, 1998·Journal of Neural Transmission. Supplementum·G F Oxenkrug, P J Requintina
May 30, 1998·British Journal of Pharmacology·G G GearyD N Krause
May 11, 1999·The American Journal of Cardiology·S AranginoG B Melis
Jun 26, 2001·Psychiatry and Clinical Neurosciences·T KitajimaT Shimisu
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Monica I MasanaDiana N Krause
Mar 4, 2003·CNS Spectrums·Gregory F Oxenkrug, Pura J Requintina
May 3, 2003·International Journal of Cardiology·Mevlut YaprakGultac Ozbay
Aug 5, 2003·Endocrine·Stephaney S PuchalskiDennis D Rasmussen
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Margarita L DubocovichMonica I Masana
Sep 13, 2003·Endocrinology·Bénédicte Prunet-MarcassusLuc Pénicaud
Feb 8, 2005·Neuropharmacology·Koki KatoMasaomi Miyamoto
Sep 24, 2005·Annals of the New York Academy of Sciences·Mary C PerianayagamBertrand L Jaber
Dec 21, 2005·American Journal of Hypertension·Angelo CagnacciAnnibale Volpe
Dec 21, 2005·American Journal of Hypertension·Frank A J L Scheer
Apr 29, 2006·European Journal of Endocrinology·Lucia PacificoClaudio Chiesa
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Murray A RaskindDennis D Rasmussen
Jun 14, 2006·Behavioral Neuroscience·Charles P FranceLance R McMahon
Sep 27, 2006·The American Journal of Medicine·Ehud GrossmanNava Zisapel
Oct 4, 2006·Archives of General Psychiatry·Matthew W JohnsonRoland R Griffiths
Apr 14, 2007·Current Drug Metabolism·G BrandacherHelmut G Weiss
Jan 26, 2008·American Journal of Hypertension·Avshalom LeibowitzEhud Grossman
Mar 28, 2008·The Journal of Clinical Psychiatry·David C Henderson
May 16, 2009·Chemical Research in Toxicology·Ding LuLisa A Peterson

❮ Previous
Next ❯

Citations

May 26, 2012·TheScientificWorldJournal·Rüdiger Hardeland
Jan 29, 2013·International Journal of Molecular Sciences·Daniel P CardinaliPablo Scacchi
Oct 12, 2013·Postgraduate Medicine·Mehrul Hasnain, W Victor R Vieweg
Aug 25, 2012·Expert Opinion on Investigational Drugs·Ludovit PaulisMoshe Laudon
Jul 17, 2010·Annals of the New York Academy of Sciences·Gregory F Oxenkrug
Dec 3, 2013·Molecular and Cellular Endocrinology·Gaia FaveroRita Rezzani
Apr 9, 2015·Frontiers in Endocrinology·Kazunari NoharaZheng Jake Chen
Oct 21, 2016·Journal of Pineal Research·Rüdiger Hardeland
Mar 16, 2018·Annals of the New York Academy of Sciences·Ayako UchinakaKohzo Nagata
Mar 18, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Belma Haliloglu, Abdullah Bereket
Aug 19, 2017·Cellular and Molecular Life Sciences : CMLS·Daniel P Cardinali, Daniel E Vigo
Jul 1, 2020·Terapevticheskiĭ arkhiv·T M OstroumovaA I Kochetkov
Jun 4, 2021·Biological & Pharmaceutical Bulletin·Airi YoshimotoNobuyoshi Matsumoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.