Abstract
In this randomized and controlled study, we evaluated the antiemetic efficacy of ramosetron combined with dexamethasone for postoperative nausea and vomiting (PONV) compared with that of dexamethasone or ramosetron alone in women who underwent laparoscopic cholecystectomy. One hundred twenty female patients were randomly assigned to one of three groups to receive antiemetics as follows: ramosetron 0.3 mg (group R), dexamethasone 8 mg (group D), or ramosetron 0.3 mg combined with dexamethasone 8 mg (group RD). PONV, postoperative pain intensity, rescue antiemetics requirement, and side effects were assessed at 0-6, 6-12, and 12-24 h after surgery. The ratio of complete response (no PONV and no rescue antiemetic) was higher at 6-12 h in groups R and RD than in group D (p < 0.05) and at 12-24 h in group RD than in group D (p < 0.05). The incidence of nausea was lower at 6-12 h in groups R (p = 0.043) and RD (p = 0.003) compared to group D and at 12-24 h in group RD (p = 0.01) compared to group D. The severity of nausea was also significantly reduced at 6-12 h in groups R and RD compared to group D (p < 0.05). There were no clinically serious adverse events related to the studied drugs. Antiemetic efficacy of the combination of ram...Continue Reading
References
Jul 1, 1992·Anesthesiology·M F Watcha, P F White
Mar 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M NaguibA Saddique
Oct 20, 1998·Anesthesiology·D SongE Zarate
Mar 17, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·V RajeevaL K Dhaliwal
Jul 17, 1999·Acta Anaesthesiologica Scandinavica·R Jokela, M Koivuranta
Sep 15, 1999·Anesthesiology·C C ApfelN Roewer
Oct 16, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y FujiiH Toyooka
Jan 7, 2000·Anesthesia and Analgesia·I HenziM R Tramèr
Apr 12, 2000·European Journal of Anaesthesiology·Y FujiiH Toyooka
Nov 7, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mokhtar ElhakimAzza Atef
Nov 20, 2002·Journal of the American College of Surgeons·Kathrine Holte, Henrik Kehlet
Apr 18, 2003·The European Journal of Surgery = Acta Chirurgica·Yoshitaka FujiiHiroyoshi Tanaka
Dec 5, 2003·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Antonio Villalon, Valorie Chan
Jun 11, 2004·The New England Journal of Medicine·Christian C ApfelUNKNOWN IMPACT Investigators
Jan 10, 2006·The British Journal of Surgery·C V FeoA Liboni
Feb 8, 2007·Surgical Endoscopy·V Nesek-AdamA Smiljanić
May 26, 2007·Clinical Drug Investigation·Jeong Hye KimYoon-Koo Kang
Nov 29, 2007·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia
Oct 25, 2008·Annals of Surgery·Paul J KaranicolasGordon H Guyatt
Aug 20, 2009·Surgical Endoscopy·Y Fujii, M Itakura
Aug 27, 2009·Surgical Endoscopy·Junghee RyuSang-Hwan Do
Feb 8, 2011·Anesthesiology·Glenn S MurphyJessica Vaughn
Mar 16, 2011·Anaesthesia·J W SongY H Shim
Citations
Jun 20, 2014·Asian Journal of Surgery·Xiao-Ying SiYan-Ming Zhou
Dec 17, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·S Y KimM D Kim
Oct 31, 2016·International Journal of Surgery·Kamal AwadAttia Attia
Nov 22, 2016·Anesthesia and Analgesia·Anirban SomDalim Kumar Baidya
Jun 15, 2013·The Journal of International Medical Research·Won Joong KimGil Hoi Koo
Nov 2, 2012·Korean journal of anesthesiology·Jung Woo ParkKi Hyuk Hong
Jan 16, 2015·The Korean Journal of Pain·Myeong Jong LeeCheol Lee
Sep 13, 2019·The Journal of International Medical Research·HyunJeong KwakYoun Yi Jo
Jun 13, 2013·Anesthesia and Analgesia·Takahiro MiharaTakahisa Goto
Nov 29, 2016·BioMed Research International·Chengmao ZhouLin Ruan
Aug 5, 2018·Medicine·Hong Soo JungJaemin Lee
Sep 12, 2020·F1000Research·Ofelia Loani Elvir-LazoHillenn Cruz Eng
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke
Jul 13, 2019·International Journal of Surgery·Kannan Sridharan, Gowri Sivaramakrishnan