Random anti-Müllerian hormone predicts ovarian response in women with high baseline follicle-stimulating hormone levels : anti-Müllerian hormone in poor responders in assisted reproductive treatment.

Journal of Assisted Reproduction and Genetics
Handan CelikA Sertaç Batuoğlu

Abstract

To evaluate the predictive value of random serum anti-Müllerian hormone (AMH) in the assessment of ovarian response in patients with diminished ovarian reserve (DOR; diagnosed after the observation of elevated baseline levels of early follicular follicle-stimulating hormone [FSH]) who were undergoing intracytoplasmic sperm injection-embryo transfer (ICSI-ET) and to compare the random serum AMH and baseline FSH levels in these patients for the prediction of poor ovarian response. Retrospective study. University hospital. One hundred and thirty-nine patients who were undergoing ICSI-ET cycles with early follicular FSH level >9 IU/mL. None. Poor ovarian response in ICSI-ET cycles. For the identification of women at risk of cycle cancellation, an AMH cut-off level ≤1.2 ng/mL had 97.3 % sensitivity, 31.3 % specificity, 33.9 % positive predictive value, and 96.9 % negative predictive value in the women with high baseline FSH levels. An AMH cut-off level ≥1 ng/mL had a sensitivity of 58.7 % and specificity of 95.1 % for prediction of retrieval of 4 or more oocytes. By using a serum AMH cutoff level of 1.5 ng/mL, the ongoing pregnancies were predicted with 83.3 % sensitivity and 82.5 % specificity and yielded a positive predictive valu...Continue Reading

References

Feb 1, 1996·The Journal of Clinical Endocrinology and Metabolism·M M LeeD T MacLaughlin
Jul 13, 1999·Human Reproduction·V Karande, N Gleicher
Nov 29, 2002·Human Reproduction·I A J van RooijA P N Themmen
Dec 6, 2003·Molecular and Cellular Endocrinology·Maria J G GruijtersAxel P N Themmen
Feb 28, 2006·Fertility and Sterility·Cem FiçiciogluZeynep Bakacak
Jun 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Wouter J K HehenkampFrank J M Broekmans
Aug 8, 2006·Human Reproduction Update·F J BroekmansC B Lambalk
Apr 30, 2008·Annals of the New York Academy of Sciences·Maria Elisabetta Coccia, Francesca Rizzello
Apr 21, 2011·Human Reproduction·A P FerrarettiUNKNOWN ESHRE working group on Poor Ovarian Response Definition

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