PMID: 7522076May 1, 1994Paper

Random-coil model for glomerular sieving of dextran

Bulletin of Mathematical Biology
J D Oliver, W M Deen

Abstract

Dextran has been the most commonly employed test molecule for probing the selectivity of glomerular filtration to macromolecules of varying size. The usual theories for hindered transport of solid spheres through pores have limited utility in interpreting clearance data for dextran or other linear polymers because such polymers in solution more closely resemble random, solvent-filled coils than solid spheres. To provide a model for glomerular filtration of random-coil macromolecules, the equilibrium partitioning of random coils between cylindrical pores and bulk solution was simulated using Monte Carlo calculations, and those results were combined with a hydrodynamic theory for restricted motion of solvent-filled polymer coils in pores. The rates of transport predicted for either neutral random coils or for solid spores of the same Stokes-Einstein radius were significantly lower than observed transport rates of dextran through the glomerular capillary wall or across synthetic porous membranes. This facilitation of dextran transport was modeled by postulating weak, attractive interactions between dextran monomers and the pore wall. The random-coil model with attractive interactions, modeled using a short-range, square-well poten...Continue Reading

References

Aug 1, 1992·Journal of the American Society of Nephrology : JASN·J D OliverW H Deen

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Citations

Feb 16, 2005·Annals of Biomedical Engineering·Roland Steck, Melissa L Knothe Tate
Jul 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Stephen E Barry
Apr 9, 2008·Physiological Reviews·Börje HaraldssonWilliam M Deen
Nov 21, 1998·The Journal of Laboratory and Clinical Medicine·A Remuzzi, G Remuzzi
Feb 23, 2012·Molecular Pharmaceutics·Yatin R GokarnThomas M Laue

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