PMID: 9420470Jan 1, 1997Paper

Random mating and selection in families against homozygotes for HLA in south Amerindians

Hereditas
P W Hedrick, F L Black

Abstract

We have examined HLA-A and HLA-B in a large sample of families of South Amerindians for non-random mating and for Mendelian segregation in their progeny. The proportion of couples sampled for mating averaged over 50% of the total matings with progeny for 10 of the 11 tribes with 10 or more known matings. In nearly all cases, HLA-sharing proportions were very close to those expected from random mating, suggesting strong negative-assortative mating for MHC is not present in these South Amerindians. In progeny from these matings and others in 23 tribes, there was a large deficiency of homozygotes (excess of heterozygotes) compared with Mendelian expectations. In particular, there was a deficiency in all types of matings except when the female was a homozygote and the male shared one allele with her; the reciprocal mating showed no such deficiency. This non-reciprocity suggests the importance of some type of maternal-fetal interaction. A model to describe these results showed very surprising properties for two alleles: no change in allelic frequency like neutrality, an excess of heterozygotes like heterozygote advantage, and a minimum fitness at intermediate allelic frequency like heterozygote disadvantage. For three or more allele...Continue Reading

References

Nov 2, 1976·The Journal of Experimental Medicine·K YamazakiL Thomas
Nov 1, 1980·Tissue Antigens·F L BlackY Gabbay
Jan 1, 1983·Immunogenetics·L T RosenbergR Payne
Jul 1, 1983·Genetics·P W Hedrick, G Thomson
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Jun 22, 1995·Proceedings. Biological Sciences·C WedekindA J Paepke
Dec 1, 1993·Trends in Genetics : TIG·W K Potts, E K Wakeland
May 8, 1997·Nature·P Hedrick
Oct 27, 1997·American Journal of Human Genetics·P W Hedrick, F L Black
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·F L Black, P W Hedrick
Aug 1, 1995·Trends in Ecology & Evolution·F Voilrath, M Milinski
Jan 1, 1996·Trends in Ecology & Evolution·P Hedrick, V Loeschcke

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