Random peptide mixtures as new crop protection agents

Microbial Biotechnology
Shiri TopmanZvi Hayouka

Abstract

Many types of crops are severely affected by at least one important bacterial disease. Chemical control of bacterial plant diseases in the field vastly relies on copper-based bactericides, yet with limited efficacy. In this study, we explored the potential of two random peptide mixture (RPM) models as novel crop protection agents. These unique peptide mixtures consist of random combination of l-phenylalanine and l- or d-lysine (FK-20 and FdK-20, respectively) along the 20 mer chain length of the peptides. Both RPMs displayed powerful bacteriostatic and bactericidal activities towards strains belonging to several plant pathogenic bacterial genera, for example, Xanthomonas, Clavibacter and Pseudomonas. In planta studies in the glasshouse revealed that RPMs significantly reduced disease severity of tomato and kohlrabi plants infected with Xanthomonas perforans and Xanthomonas campestris pv. campestris respectively. Moreover, RPM effects on reduction in disease severity were similar to those exerted by the commercial copper-based bactericide Kocide 2000 that was applied at a 12-fold higher concentration of the active compound relative to the RPM treatments. Importantly, the two tested RPM compounds had no toxic effect on survival o...Continue Reading

References

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May 11, 2016·Chemical Communications : Chem Comm·Tal SternZvi Hayouka

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Citations

Sep 10, 2020·Chemical Communications : Chem Comm·Shiri Topman-RakoverZvi Hayouka
May 2, 2020·Science·Brian P LazzaroJens Rolff
Jan 29, 2019·Chemical Communications : Chem Comm·Zaid Amso, Zvi Hayouka
Sep 23, 2020·Chemical Communications : Chem Comm·Hadar CherikerZvi Hayouka
Dec 30, 2020·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Nina Wiedmaier-CzernyWalter Vetter
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nuno Mariz-PonteCátia Teixeira
Jul 3, 2021·International Journal of Molecular Sciences·Àngel OliverasLidia Feliu
Sep 3, 2021·Molecular Plant Pathology·Ebrahim OsdaghiGary E Vallad

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