PMID: 15244621Jul 13, 2004Paper

Random walks of molecular motors arising from diffusional encounters with immobilized filaments

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Theo M NieuwenhuizenReinhard Lipowsky

Abstract

Movements of molecular motors on cytoskeletal filaments are described by directed walks on a line. Detachment from this line is allowed to occur with a small probability. Motion in the surrounding fluid is described by symmetric random walks. Effects of detachment and reattachment are calculated by an analytical solution of the master equation in two and three dimensions. Results are obtained for the fraction of bound motors, their average velocity, displacement, and dispersion. The analytical results are in good agreement with results from Monte Carlo simulations and confirm the behavior predicted by scaling arguments. The diffusion coefficient parallel to the filament becomes anomalously large since detachment and subsequent reattachment, in the presence of directed motion of the bound motors, leads to a broadening of the density distribution. The occurrence of protofilaments on a microtubule is modeled by internal states of the binding sites. After a transient time, all protofilaments become equally populated.

References

Aug 17, 1999·Nature·A D MehtaR E Cheney
Sep 5, 2001·Physical Review Letters·R LipowskyT M Nieuwenhuizen
Dec 12, 2001·Nature Cell Biology·Claudia VeigelJustin E Molloy
Mar 14, 2003·Physical Review Letters·A ParmeggianiE Frey

❮ Previous
Next ❯

Citations

Jul 4, 2006·Biophysical Journal·Karl I SkauMatthew S Turner
Jul 26, 2005·Biophysical Journal·Hanna SalmanMichael Elbaum
Apr 28, 2005·Biophysical Journal·Stefan KlumppReinhard Lipowsky
Nov 30, 2005·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Melanie J I MüllerReinhard Lipowsky
Dec 10, 2015·Physical Review Letters·O BénichouR Voituriez
Dec 31, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·T Antal, P L Krapivsky
Feb 21, 2006·Physical Review Letters·Stefan Klumpp, Reinhard Lipowsky
Apr 16, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Nadezhda BunzarovaJordan Brankov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.