Randomised clinical trial: faecal microbiota transplantation by colonoscopy plus vancomycin for the treatment of severe refractory Clostridium difficile infection-single versus multiple infusions

Alimentary Pharmacology & Therapeutics
G IaniroGiovanni Cammarota

Abstract

Faecal microbiota transplantation (FMT) is a highly effective treatment against recurrent Clostridium difficile infection. Far less evidence exists on the efficacy of FMT in treating severe Clostridium difficile infection refractory to antibiotics. To compare the efficacy of two FMT-based protocols associated with vancomycin in curing subjects with severe Clostridium difficile infection refractory to antibiotics. Subjects with severe Clostridium difficile infection refractory to antibiotics were randomly assigned to one of the two following treatment arms: (1) FMT-S, including a single faecal infusion via colonoscopy followed by a 14-day vancomycin course, (2) FMT-M, including multiple faecal infusions plus a 14-day vancomycin course. In the FMT-M group, all subjects received at least two infusions, while those with pseudomembranous colitis underwent further infusions until the disappearance of pseudomembranes. The primary outcome was the cure of refractory severe Clostridium difficile infection. Fifty six subjects, 28 in each treatment arm, were enrolled. Twenty one patients in the FMT-S group and 28 patients in the FMT-M group were cured (75% vs 100%, respectively, both in per protocol and intention-to-treat analyses; P = 0.0...Continue Reading

Associated Clinical Trials

References

Jul 24, 2002·The American Journal of Gastroenterology·Lynne V McFarlandChristina M Surawicz
Mar 25, 2010·BMJ : British Medical Journal·Kenneth F SchulzUNKNOWN CONSORT Group
Apr 5, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Becky A MillerDeverick J Anderson
Jul 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erik R Dubberke, Margaret A Olsen
Jan 18, 2013·The New England Journal of Medicine·Els van NoodJosbert J Keller
Feb 27, 2013·The American Journal of Gastroenterology·Christina M SurawiczBrian S Zuckerbraun
May 2, 2013·Journal of Clinical Gastroenterology·Alexa R WeingardenAlexander Khoruts
Oct 15, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S B DebastUNKNOWN European Society of Clinical Microbiology and Infectious Diseases
Mar 29, 2014·American Journal of Surgery·Kai B DallasCelia M Divino
Feb 7, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M A OlsenE R Dubberke
Feb 26, 2015·The New England Journal of Medicine·Fernanda C LessaL Clifford McDonald
May 2, 2015·Anaerobe·Kelsey ShieldsCiaran P Kelly
May 6, 2015·Annals of Internal Medicine·Dimitri DrekonjaTimothy J Wilt
Nov 29, 2016·Alimentary Pharmacology & Therapeutics·J KönigR J Brummer
Jan 7, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G IaniroG Cammarota
Jan 15, 2017·Gut·Giovanni CammarotaUNKNOWN European FMT Working Group

❮ Previous
Next ❯

Citations

Oct 10, 2018·Surgical Infections·Raghavendra Paknikar, Joel Pekow
Dec 19, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Berkeley N LimketkaiAlyssa M Parian
Mar 8, 2019·Expert Opinion on Emerging Drugs·Giovanni CammarotaMassimo Montalto
Apr 25, 2019·The Kaohsiung Journal of Medical Sciences·Wen-Hung HsuChao-Hung Kuo
Nov 7, 2019·Expert Opinion on Biological Therapy·Vinod Kumar, Monika Fischer
Mar 1, 2019·Current Gastroenterology Reports·Hamzah Abu-SbeihYinghong Wang
Nov 22, 2019·Journal of Applied Microbiology·G QuarantaL Masucci
Feb 15, 2020·Expert Review of Anti-infective Therapy·Yao-Wen Cheng, Monika Fischer
Feb 23, 2020·Expert Opinion on Biological Therapy·Loris R LopetusoGiovanni Cammarota
Apr 9, 2020·Expert Review of Anti-infective Therapy·Elida Voth, Sahil Khanna
Apr 16, 2020·Journal of Gastroenterology and Hepatology·Antonella GalloMassimo Montalto
Dec 13, 2019·Journal of Gastroenterology and Hepatology·Annie S HongMahendran Jayaraj
May 6, 2020·Minerva anestesiologica·Radislav NakovGianluca Ianiro
Aug 24, 2020·Journal of Leukocyte Biology·Rodrigo Emanuel Hernández Del PinoVirginia Pasquinelli
Sep 22, 2020·Future Microbiology·Gianluca IaniroGiovanni Cammarota
Jan 16, 2020·Intensive Care Medicine·Massimo AntonelliMaria Sole Vallecoccia
Apr 14, 2020·European Journal of Gastroenterology & Hepatology·Qianqian LiFaming Zhang
Apr 17, 2020·AAPS PharmSciTech·Hala M Fadda
Jun 15, 2019·The Kaohsiung Journal of Medical Sciences·Jiunn-Wei WangWen-Hung Hsu
Aug 23, 2019·BMJ : British Medical Journal·Benoit GueryFrédéric Barbut
Jul 6, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Anne A RodeJørgen Engberg
Mar 10, 2020·World Journal of Gastroenterology : WJG·Akshita GuptaSahil Khanna
Nov 21, 2019·Current Treatment Options in Gastroenterology·Yao-Wen Cheng, Monika Fischer
Jan 11, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Yao-Wen ChengMonika Fischer
Oct 30, 2020·Microorganisms·Nicola PrincipiSusanna Esposito
Nov 3, 2020·World Journal of Gastroenterology : WJG·Quan WenFa-Ming Zhang
Nov 13, 2020·European Journal of Gastroenterology & Hepatology·Aravind Gokul Tamilarasan, Thanuja Krishnananthan
Feb 23, 2021·Therapeutic Advances in Infectious Disease·Simon D Goldenberg, Blair Merrick
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Paulina ŻebrowskaŁukasz Łaczmański
Mar 9, 2021·Journal of Gastroenterology and Hepatology·Sanchit GuptaJessica R Allegretti
Oct 31, 2020·Gastroenterology Clinics of North America·Yao-Wen Cheng, Monika Fischer
Jan 20, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sarah K McGill
Apr 15, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Catherine M Cappetto
May 8, 2021·Therapeutic Advances in Gastroenterology·Devvrat Yadav, Sahil Khanna

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.