PMID: 8601999Mar 16, 1996Paper

Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy

Lancet
M de SilvaE H Reynolds

Abstract

The medical treatment of childhood epilepsy is largely influenced by clinical trials in adult patients. We know of only one randomised comparative trial (of two drugs) in newly diagnosed childhood epilepsy. We have undertaken a long-term, prospective, randomised, unmasked, pragmatic trial of the comparative efficacy and toxicity of four standard antiepileptic drugs used as monotherapy in children with newly diagnosed epilepsy. Between 1981 and 1987, 167 children aged 3-16 years, who had had at least two previously untreated tonic-clonic or partial seizures, with or without secondary generalisation, were randomly allocated treatment with phenobarbitone, phenytoin, carbamazepine, or sodium valproate. The protocol was designed to conform to standard clinical practice. Efficacy was assessed by time to first seizure after the start of treatment and time to achieving 1-year remission. The overall outcome with all four drugs was good. 20% of children remained free of seizures and 73% had achieved 1-year remission by 3 years of follow-up. We found no significant differences between the drugs for either measure of efficacy at 1, 2, or 3 years of follow-up. The overall frequency of unacceptable side-effects necessitating withdrawal of th...Continue Reading

References

Sep 1, 1979·The Journal of Pediatrics·C S CamfieldP R Camfield
Jun 25, 1977·British Medical Journal·S D Shorvon, E H Reynolds
Nov 26, 1988·BMJ : British Medical Journal·S Shorvon
Mar 16, 1985·British Medical Journal·D M TurnbullD W Chadwick
Nov 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·D Chadwick, D M Turnbull
Nov 1, 1985·Neurology·P R CamfieldB Garner
Oct 11, 1984·The New England Journal of Medicine·R D ElwesE H Reynolds
Nov 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·S D Shorvon

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Citations

Sep 14, 2002·Statistics in Medicine·Paula R WilliamsonDavid W Chadwick
Oct 31, 2002·Statistics in Medicine·Paula R WilliamsonAnthony G Marson
Mar 18, 2004·Research in Developmental Disabilities·Johnny L MatsonStephen B Mayville
May 27, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·I O OnwuekweC Onyejizu
Aug 3, 2001·Pediatric Neurology·A VerrottiF Chiarelli
Aug 15, 2000·Epilepsy Research·E PeruccaT Tomson
Jul 20, 2001·Epilepsy Research·E Perucca
Nov 26, 2002·Epilepsy Research·Gregory L Holmes
Jun 1, 1997·Seizure : the Journal of the British Epilepsy Association·M J Brodie, M A Dichter
Apr 1, 1997·Seizure : the Journal of the British Epilepsy Association·D EasterC Verity
Jan 15, 1999·Seizure : the Journal of the British Epilepsy Association·M Baldy-MoulinierE Perucca
Mar 1, 2003·Epilepsy & Behavior : E&B·Johannes A. CarpayWillem F.M. Arts
Jun 26, 2001·Epilepsia·F M Besag
Aug 25, 2001·Epilepsia·E Perucca
Dec 12, 2001·Epilepsia·P Kwan, M J Brodie
May 25, 2002·Epilepsia·Anthony G MarsonUNKNOWN Epilepsy Monotherapy Trial Group
Sep 27, 2003·Epilepsia·Rocio Sánchez-Carpintero, Brian G R Neville
Mar 13, 2002·European Journal of Pain : EJP·Emilio Perucca
Aug 31, 2002·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Amal BassiliUNKNOWN Egyptian-Italian Collaborative Group on Paediatric Chronic Diseases
Feb 23, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Frank M C Besag
Nov 29, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J JedrzejczakUNKNOWN VIPe Study Group
Mar 26, 2009·Epilepsia·Edward H Reynolds
May 18, 1999·Archives of Disease in Childhood·M C RudolfV Kaur
Jan 8, 1999·BMJ : British Medical Journal·M Feely
Apr 9, 2005·BMJ : British Medical Journal·Edward H Reynolds
Mar 11, 2006·BMJ : British Medical Journal·Edward Reynolds
Dec 6, 2006·BMJ : British Medical Journal·Selina H BanuBrian Neville
Mar 31, 2007·Trials·Paula R WilliamsonAnthony G Marson
Nov 7, 2007·Trials·Catrin Tudur SmithPaula R Williamson
Jul 14, 2012·Drug, Healthcare and Patient Safety·Amy Z CrepeauElaine C Wirrell
Nov 19, 2003·Psychopharmacology Bulletin·Michael J Owens, Charles B Nemeroff
Feb 12, 2004·CNS Drugs·Giangennaro Coppola

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