PMID: 8597678Feb 24, 1996Paper

Randomised comparison of oestrogen versus oestrogen plus progestogen hormone replacement therapy in women with hysterectomy. Medical Research Council's General Practice Research Framework

BMJ : British Medical Journal

Abstract

To compare the acceptability and symptomatic and metabolic effects of two regimens of hormone replacement therapy in women with hysterectomy. Randomised, double blind comparison. Seven group practices in the Medical Research Council's general practice research framework. 321 women with hysterectomy aged 35-59. Hormone replacement therapy with (a) conjugated equine oestrogen 625 micrograms daily alone or (b) conjugated equine oestrogen 625 micrograms daily plus the progestogen norgestrel 150 micrograms daily for the last 12 days of the 'cycle.' Changes in blood pressure, weight, symptoms, and haemostatic and lipid values. After two years 36% (57/158) of women randomly allocated to take oestrogen alone had discontinued treatment as compared with 30% (49/163) of women allocated to take oestrogen plus progestogen. Smokers were more likely to withdraw than non-smokers. There were no clear differences between the two groups in symptoms often attributed to hormone replacement therapy or in blood pressure or weight. At one year low density lipoprotein cholesterol concentrations had fallen substantially in both groups. High density lipoprotein cholesterol concentrations rose to significantly higher values in women taking oestrogen alone...Continue Reading

References

Jan 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·L MussoniE Tremoli
Jan 1, 1992·Annals of Epidemiology·T A ManolioW R Harlan
Oct 1, 1992·British Journal of Obstetrics and Gynaecology·M FalkebornT Naessén
Oct 26, 1991·Lancet·G J MillerR D Rosenberg
Feb 1, 1991·The American Journal of Medicine·J C GallagherD Goldgar
Sep 4, 1987·JAMA : the Journal of the American Medical Association·W B KannelR B D'Agostino
Oct 11, 1993·Archives of Internal Medicine·S M VaziriP W Wilson
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J HeinrichJ van de Loo
May 24, 1993·Archives of Internal Medicine·M FalkebornR Bergström
May 1, 1993·The Journal of Clinical Investigation·B W Walsh, F M Sacks

❮ Previous
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Citations

Nov 15, 2002·International Journal of Hematology·Kwang Kon Koh
Jul 22, 1999·Social Science & Medicine·F Griffiths
Mar 24, 2004·Maturitas·Anna H KarjalainenY Antero Kesäniemi
Jun 1, 1997·Endocrinology and Metabolism Clinics of North America·M M Sotelo, S R Johnson
Nov 17, 2001·European Journal of Internal Medicine·P M Mannucci
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Kenan Saglam
Aug 31, 2001·Menopause : the Journal of the North American Menopause Society·F P ChenK E Huang
Oct 23, 1997·British Journal of Obstetrics and Gynaecology·D W Sturdee
Jul 21, 2000·Aging : Clinical and Experimental Research·L FerrucciF Lauretani
Dec 16, 2000·BMJ : British Medical Journal·J Rymer, E P Morris
Jul 28, 1999·Journal of Psychosomatic Obstetrics and Gynaecology·L A RossA E Gebbie
Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·F Imoh-ItaJ Rymer
Sep 12, 2006·Obstetrics and Gynecology Clinics of North America·Isobel D Walker
Aug 4, 1998·The American Journal of Medicine·D Grady, G Sawaya
Jul 27, 2001·British Journal of Haematology·M CushmanL H Kuller
Sep 8, 2000·Stroke; a Journal of Cerebral Circulation·E EdmundsG Y Lip
Dec 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·G W de Valk-de RooC Netelenbos
Apr 4, 1998·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A Nasr, M Breckwoldt
Oct 16, 1999·Annals of Internal Medicine·S E McNagny
Sep 19, 2002·Journal of the American Podiatric Medical Association·Arthur H Friedlander, Lester J Jones

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