Randomised comparison of percutaneous left ventricular assist device with open-chest cardiac massage and with surgical assist device during ischaemic cardiac arrest

Resuscitation
Vegard TusethJan Erik Nordrehaug

Abstract

A percutaneous left ventricular assist device can maintain blood flow to vital organs during ventricular fibrillation and may improve outcomes in ischaemic cardiac arrest. We compared haemodynamic and clinical effects of a percutaneous left ventricular assist device with a larger device deployed via endovascular prosthesis and with open-chest cardiac massage during ischaemic cardiac arrest. Eighteen swine were randomised into three groups. After thoracotomy, coronary ischaemia and ventricular fibrillation was induced. Cardiac output was measured with transit-time flowmetry. Tissue perfusion was measured with microspheres. Defibrillation was performed after 20 min. Cardiac output with cardiac massage was 1129 mL min⁻¹ vs. 1169 mL min⁻¹ with the percutaneous- and 570 mL min⁻¹ with the surgical device (P < 0.05 surgical vs. others). End-tidal CO₂ was 3.3 kPa with cardiac massage vs. 3.2 kPa with the percutaneous- and 2.3 kPa with the surgical device (P < 0.05 surgical vs. others). Subepicardial perfusion was 0.33 mL min⁻¹ g⁻¹ with cardiac massage vs. 0.62 mL min⁻¹ g⁻¹ with both devices (P < 0.05 devices vs. massage), cerebral perfusion was comparable between groups (all reported values after 3 min cardiac arrest, all P<0.05 vs. ba...Continue Reading

References

Nov 1, 1990·Journal of the American College of Cardiology·J SegalT D Schuenemeyer
Sep 8, 1989·JAMA : the Journal of the American Medical Association·A B SandersG A Ewy
Apr 1, 1986·Annals of Emergency Medicine·W M BarnettP Safar
Mar 1, 1980·Critical Care Medicine·W D VoorheesW A Tacker
Aug 31, 2001·Journal of the American College of Cardiology·E K KerutT D Giles
Sep 27, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Maurice RemmelinkJan Baan
Feb 23, 2008·Critical Care : the Official Journal of the Critical Care Forum·Stig MüllerTruls Myrmel
Feb 27, 2009·Critical Care Medicine·Vegard TusethJan Erik Nordrehaug
Jun 16, 2009·Journal of Biomechanics·Brandon R TravisFrancis Robicsek

❮ Previous
Next ❯

Citations

Apr 24, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Roberto J CubedduIgor F Palacios
Mar 22, 2012·Critical Care Clinics·Matthias Derwall, Michael Fries
Oct 28, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Erik J S PackerJan Erik Nordrehaug
Mar 25, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Erik J S PackerVegard Tuseth
Nov 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Erik J S PackerVegard Tuseth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.