Randomised comparison of the FerX Ella antireflux stent and the ultraflex stent: proton pump inhibitor combination for prevention of post-stent reflux in patients with esophageal carcinoma involving the esophago-gastric junction

Journal of Gastroenterology and Hepatology
T SabharwalA Adam

Abstract

Metal stents placed across the gastroesophageal junction in patients with malignant dysphagia frequently present with reflux symptoms. We compared an antireflux stent with a standard open stent used in combination with proton pump inhibitor medication. Forty-nine patients with dysphagia due to inoperable carcinoma in the lower third of the esophagus were randomly selected to receive either a antireflux valve stent (FerX-Ella) (n = 22) or a covered standard open stent (Ultraflex), which was combined with proton pump inhibitors such as omeprazole (n = 26). The technical success, the presence of reflux, and complications were recorded. Reflux was seen in 3/22 patients (13.6%) in the FerX-Ella group and in 2/26 patients (7.7%) in the Ultraflex and proton pump inhibitor combination group (P-value not significant). In both groups, a significant improvement in the dysphagia score was seen and no statistically significant difference was detected between the two groups (P = 0.84). The FerX-Ella stents migrated more frequently (32%) than the Ultraflex stents (23%). This also necessitated surgical intervention more frequently in the FerX-Ella group (2/22, 9.1%) compared to the Ultraflex group (1/26, 3.8%). The antireflux stent had no demo...Continue Reading

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Citations

Jun 4, 2010·Cardiovascular and Interventional Radiology·Konstantinos KatsanosAndreas Adam
Oct 13, 2011·ISRN Gastroenterology·Juan Carlos MartinezRoderick M Quiros
Jun 21, 2011·Gastrointestinal Endoscopy Clinics of North America·F P Vleggaar, P D Siersema
Sep 22, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Jae Jun ParkJae Bock Chung
May 9, 2015·Diagnostic and Interventional Imaging·B MalgrasP Soyer
Dec 14, 2017·Nature Reviews. Gastroenterology & Hepatology·Peter S N van RossumRichard van Hillegersberg
Oct 20, 2011·The American Journal of Gastroenterology·Laetitia R H de WijkersloothPeter D Siersema
Oct 28, 2011·Expert Review of Medical Devices·Meike Madeleine Catharine HirdesPeter Derk Siersema
Jul 25, 2019·World Journal of Gastroenterology : WJG·Kai YangYing-Sheng Cheng
Oct 31, 2014·The Cochrane Database of Systematic Reviews·Yingxue DaiShujuan Yang
Jun 6, 2017·Journal of Korean Medical Science·Kun Yung KimJung Hoon Park

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