PMID: 9175950May 1, 1997Paper

Randomised controlled double blind study of role of recombinant erythropoietin in the prevention of chronic lung disease

Archives of Disease in Childhood. Fetal and Neonatal Edition
G GriffithsM I Levene

Abstract

To evaluate the role of recombinant human erythropoietin (R-HuEpo) in reducing iron infusion, which may exacerbate free radical damage, leading to chronic lung disease. A multicentre, randomised, placebo controlled, double blind study was carried out in four neonatal intensive care units in Yorkshire. Infants were randomly allocated and received either R-HuEpo (480 U/kg/wk) or placebo by twice weekly subcutaneous injection. The primary outcome measure was the number of days on respiratory support and a secondary outcome the number of blood transfusions required. Forty two very low birthweight (VLBW) infants were randomly allocated. There was little difference in the need for respiratory support one month after randomisation, but subsequently there was a trend towards a reduction in the proportion requiring respiratory support in the R-HuEpo group (difference at three months -0.50, 95% confidence interval -1.00, 0.17). During stay in hospital, the median number of blood transfusions was lower for infants in the R-HuEpo group (difference in medians -2, 95% CI -4, 0). The study was stopped early because of failure to recruit babies at the expected rate. R-HuEpo seems to reduce the number of days in oxygen for ill VLBW infants. The...Continue Reading

References

Dec 1, 1988·American Journal of Diseases of Children·J L Sullivan
Jul 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·P WilliamsonM Levene
Sep 1, 1996·Pediatric Research·F M Bany-MohammedM Hallman

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Citations

Jan 2, 2004·Indian Journal of Pediatrics·M Mahapatra, V P Choudhry
Jan 5, 2002·Early Human Development·X Carbonell-Estrany, J Figueras-Aloy
Oct 3, 2006·Current Opinion in Anaesthesiology·F F WagnerB Kubanek
May 5, 1999·Current Opinion in Hematology·G Rondini, G Chirico
Aug 5, 2003·Postgraduate Medical Journal·T NgI Macdougall
Jul 17, 1998·Pediatric Research·S P WardleA M Weindling
Oct 7, 2005·Journal of Perinatal Medicine·Xavier Carbonell-EstranyEnriqueta Alvarez
Feb 26, 2000·Clinics in Perinatology·P J Aggett
Apr 15, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Satoshi OhnishiHaruo Shintaku
Feb 19, 2019·The Cochrane Database of Systematic Reviews·Sanjay M Aher, Arne Ohlsson
Apr 25, 2014·The Cochrane Database of Systematic Reviews·Sanjay M Aher, Arne Ohlsson
Jan 29, 2020·The Cochrane Database of Systematic Reviews·Sanjay M Aher, Arne Ohlsson

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