Randomised controlled feasibility trial of real versus sham repetitive transcranial magnetic stimulation treatment in adults with severe and enduring anorexia nervosa: the TIARA study.

BMJ Open
Bethan DaltonU Schmidt

Abstract

Treatment options for severe, enduring anorexia nervosa (SE-AN) are limited. Non-invasive neuromodulation is a promising emerging intervention. Our study is a feasibility randomised controlled trial of repetitive transcranial magnetic stimulation (rTMS) in individuals with SE-AN, which aims to inform the design of a future large-scale trial. Double-blind, parallel group, two-arm, sham-controlled trial. Specialist eating disorders centre. Community-dwelling people with anorexia nervosa, an illness duration of ≥3 years and at least one previous completed treatment. Participants received 20 sessions (administered over 4 weeks) of MRI-guided real or sham high-frequency rTMS to the left dorsolateral prefrontal cortex in addition to treatment-as-usual. Primary outcomes were recruitment, attendance and retention rates. Secondary outcomes included body mass index (BMI), eating disorder symptoms, mood, quality of life and rTMS safety and tolerability. Assessments were conducted at baseline, post-treatment and follow-up (ie, at 0 month, 1 month and 4 months post-randomisation). Thirty-four participants (17 per group) were randomly allocated to real or sham rTMS. One participant per group was withdrawn prior to the intervention due to saf...Continue Reading

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Citations

Dec 4, 2019·Current Diabetes Reports·Rebecca DendyMarci E Gluck
Dec 14, 2019·The Journal of Nervous and Mental Disease·Joel Yager
May 3, 2020·The International Journal of Eating Disorders·Stephen A WonderlichHans W Hoek
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Jul 25, 2020·European Eating Disorders Review : the Journal of the Eating Disorders Association·Bethan DaltonUlrike Schmidt
Mar 30, 2020·The Journal of Nervous and Mental Disease·Joel Yager
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Feb 19, 2021·European Eating Disorders Review : the Journal of the Eating Disorders Association·Fernando Fernández-ArandaSusana Jiménez-Murcia
Mar 25, 2021·The International Journal of Eating Disorders·Tracey WadeJanet Treasure
May 22, 2021·Translational Psychiatry·Sophie PauligkStefan Ehrlich
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Dec 9, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Johanna Louise KeelerHubertus Himmerich

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Methods Mentioned

BETA
cognitive behavioural therapy

Software Mentioned

Brainsight neuronavigation

Related Concepts

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Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.