PMID: 2493302Jan 14, 1989Paper

Randomised controlled trial of interferon alfa (lymphoblastoid interferon) in chronic non-A non-B hepatitis

BMJ : British Medical Journal
M R JacynaH C Thomas

Abstract

To determine the effect of low dose interferon alfa (human lymphoblastoid interferon) on aminotransferase activities in chronic non-A non-B hepatitis. Prospective randomised controlled parallel group study of active treatment versus no treatment carried out over 16 weeks and preceded by baseline measurements at weeks 8 and 4 and time zero. HEPATOLOGY outpatient clinics in secondary referral centres. Fourteen adults with histologically proved chronic hepatitis and persistently raised aminotransferase activities for six months or more. Seven patients randomised to receive interferon alfa 5 megaunits (MU) daily for one week, reducing to 5 MU thrice weekly for seven weeks, then 3 MU thrice weekly for eight weeks. Controls not treated. Control of hepatic enzyme activity in chronic non-A non-B hepatitis. Serum aspartate aminotransferase activity remained raised in controls (mean increase in study period 23.4 U/l) but fell rapidly to normal in the treated group (mean decrease 106.4 U/l). In four cases values were normal by eight weeks and in five cases by 16 weeks. Only minor side effects were recorded (fever, myalgia), which became less common as treatment progressed. Continuous low dose interferon alfa reduces aspartate aminotransfe...Continue Reading

References

May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PignatelliH C Thomas
Nov 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A VallbrachtB Flehmig
Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A McDonaldH C Thomas
Dec 18, 1986·The New England Journal of Medicine·J H HoofnagleE A Jones
Mar 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B LeggettL W Powell
Jan 1, 1985·Journal of Medical Virology·S C PappasE A Jones
Nov 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S V FeinmanJ E Maynard

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Citations

Aug 1, 1989·Irish Journal of Medical Science·D G Weir
Jan 1, 1995·Seminars in Gastrointestinal Disease·N N Zein, J Rakela
Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A P Choksi, H G Desai
Sep 1, 1990·Baillière's Clinical Gastroenterology·N Sheron, G J Alexander
Jan 6, 2000·Journal of Hepatology·H C ThomasS D Taylor-Robinson
Jul 1, 1996·Baillière's Clinical Gastroenterology·G L Davis
Jan 1, 1994·European Journal of Clinical Investigation·B RehermannM P Manns
May 1, 1994·Journal of Gastroenterology and Hepatology·J RyanF Dudley
Oct 1, 1995·Gut·J C BoothH C Thomas
Dec 1, 1990·Postgraduate Medical Journal·M R Jacyna, H C Thomas
Mar 15, 1997·Medizinische Klinik·D M Alscher, J C Bode
Aug 27, 2011·Clinics in Liver Disease·Maria Buti, Rafael Esteban
Jan 1, 1993·Journal of Hepatology·J H HoofnagleM Shindo
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Ruiz-MorenoV Carreño
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M Di Bisceglie, J H Hoofnagle
Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·X M LiE R Schiff
Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N ManabeJ A Grimaud
Sep 1, 1994·Human & Experimental Toxicology·J O SieckP Ernst
Sep 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R L Koretz
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MarcellinJ P Benhamou
Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Sáez-RoyuelaV Carreño
Jul 1, 1992·Journal of Medical Virology·V CarreñoI Castillo
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E BoucherY Deugnier
Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J BrownH C Thomas

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