PMID: 9797626Nov 3, 1998Paper

Randomised, controlled trial of nasal continuous positive airway pressure in the extubation of infants weighing 600 to 1250 g

Archives of Disease in Childhood. Fetal and Neonatal Edition
Peter G DavisP Henschke

Abstract

To determine whether extubation to nasal continuous airway pressure (NCPAP) results in a greater proportion of infants remaining free of additional ventilatory support for one week after extubation compared with those extubated directly to headbox oxygen. A randomised, controlled, clinical trial was conducted at the neonatal intensive care unit of the Royal Women's Hospital, Melbourne, of infants with birthweights between 600 and 1250 g, ventilated via an endotracheal tube for more than 12 hours, requiring less than 50% oxygen, a ventilator rate < or = 20/minute, considered by the clinical management team to be ready for extubation. Infants were randomly allocated either to NCPAP or to oxygen administered via a headbox. Success was defined by no requirement for additional ventilatory support over the week following extubation. Failure criteria were (i) apnoea; (ii) absolute increase in oxygen requirement greater than 15% above than required before extubation; or (iii) respiratory acidosis (pH < 7.25 with pCO2 > 6.67 kPa). Thirty one of 47 (66%) infants were successfully extubated to NCPAP compared with 18 of 45 (40%) for headbox oxygen. The increase in failure rate in the headbox group was due primarily to increased oxygen requ...Continue Reading

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Citations

Apr 18, 2008·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Lisa McCoskey
Nov 16, 2007·The Journal of Perinatal & Neonatal Nursing·Debbie Fraser Askin
Dec 17, 2011·European Journal of Pediatrics·Olie ChowdhuryAnne Greenough
Sep 12, 2013·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Katherine M NewnamW Thomas Bass
Aug 2, 2015·European Journal of Pediatrics·Yue YinDavid A Todd
Mar 31, 2007·Clinics in Perinatology·Sherry E Courtney, Keith J Barrington
Mar 15, 2006·Clinics in Perinatology·Louis P Halamek, Colin Morley
Jan 30, 2009·Neonatal Network : NN·Amanda Jayne Squires, Marilyn Hyndman
Jul 29, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·G VentoC Romagnoli
May 5, 2000·The Cochrane Database of Systematic Reviews·P G Davis, D J Henderson-Smart
Aug 1, 1999·Journal of Paediatrics and Child Health·P G Davis, D J Henderson-Smart
Feb 2, 2021·Journal of Neonatal-perinatal Medicine·Z B PuthattayilS L Lawrence
Jun 14, 2003·The Cochrane Database of Systematic Reviews·P G Davis, D J Henderson-Smart

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