PMID: 9797626Nov 3, 1998Paper

Randomised, controlled trial of nasal continuous positive airway pressure in the extubation of infants weighing 600 to 1250 g

Archives of Disease in Childhood. Fetal and Neonatal Edition
Peter G DavisP Henschke


To determine whether extubation to nasal continuous airway pressure (NCPAP) results in a greater proportion of infants remaining free of additional ventilatory support for one week after extubation compared with those extubated directly to headbox oxygen. A randomised, controlled, clinical trial was conducted at the neonatal intensive care unit of the Royal Women's Hospital, Melbourne, of infants with birthweights between 600 and 1250 g, ventilated via an endotracheal tube for more than 12 hours, requiring less than 50% oxygen, a ventilator rate < or = 20/minute, considered by the clinical management team to be ready for extubation. Infants were randomly allocated either to NCPAP or to oxygen administered via a headbox. Success was defined by no requirement for additional ventilatory support over the week following extubation. Failure criteria were (i) apnoea; (ii) absolute increase in oxygen requirement greater than 15% above than required before extubation; or (iii) respiratory acidosis (pH < 7.25 with pCO2 > 6.67 kPa). Thirty one of 47 (66%) infants were successfully extubated to NCPAP compared with 18 of 45 (40%) for headbox oxygen. The increase in failure rate in the headbox group was due primarily to increased oxygen requ...Continue Reading


Sep 1, 1985·Early Human Development·D FieldI E Hopkin
Jun 17, 1971·The New England Journal of Medicine·G A GregoryW K Hamilton
Apr 1, 1982·American Journal of Diseases of Children·S C EngelkeL R Kuhns
May 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·B H SoS Kamoshita
May 1, 1993·Archives of Disease in Childhood·V Chan, A Greenough

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