PMID: 2505689Jun 1, 1989Paper

Randomised controlled trial of two methods of weaning from high frequency positive pressure ventilation

Archives of Disease in Childhood
A GreenoughH Gamsu

Abstract

Forty preterm infants suffering from respiratory distress syndrome were entered into a randomised controlled trial to assess the importance of the length of inspiratory time during weaning from high frequency positive pressure ventilation (HFPPV). Two weaning regimes were compared: in one (group A) inspiratory time was limited to 0.5 seconds throughout weaning, in the other (group B) ventilator rate was reduced by increasing both inspiratory and expiratory time (inspiration:expiration ratio constant) until inspiratory time reached 1.0 seconds. At ventilator rates of 20 and 40 breaths/minute an acute comparison was made in all 40 infants of the two inspiratory times; despite the lower mean airway pressure associated with the shorter inspiratory time blood gases were maintained. There was no difference in the incidence of pneumothoraces or need for reventilation between the two regimens but infants in group A had a shorter duration of weaning. We conclude limitation of inspiratory time to 0.5 seconds during weaning from HFPPV is advantageous to preterm infants with respiratory distress syndrome.

References

May 1, 1988·Early Human Development·A Greenough
Sep 1, 1987·Acta paediatrica Scandinavica·A GreenoughH Gamsu
Dec 1, 1987·Archives of Disease in Childhood·A GreenoughH R Gamsu
May 1, 1987·Archives of Disease in Childhood·C A Ramsden, E O Reynolds
Sep 1, 1987·European Journal of Pediatrics·A Greenough, A D Milner
Apr 1, 1986·Early Human Development·A GreenoughJ Pool
Mar 1, 1985·Archives of Disease in Childhood·D FieldI E Hopkin
Oct 1, 1985·Early Human Development·A GreenoughJ A Davis
Nov 1, 1984·Archives of Disease in Childhood·A GreenoughN R Roberton
Nov 1, 1983·The Journal of Pediatrics·A GreenoughJ Davis

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Citations

Oct 1, 1990·Archives of Disease in Childhood·A Greenough
May 1, 1993·Archives of Disease in Childhood·V Chan, A Greenough
May 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·G DimitriouV Chan
Jan 1, 1991·Journal of Perinatal Medicine·A GreenoughV Chan
Oct 21, 2004·The Cochrane Database of Systematic Reviews·C O F Kamlin, P G Davis
Mar 10, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Wissam ShalishGuilherme Mendes Sant'Anna
May 3, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Martin Keszler

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