PMID: 22579007May 15, 2012Paper

Randomised, double-blind, placebo-controlled study of a single dose of an amylmetacresol/2,4-dichlorobenzyl alcohol plus lidocaine lozenge or a hexylresorcinol lozenge for the treatment of acute sore throat due to upper respiratory tract infection

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques
Damien McNallyEmma Field

Abstract

Sore throat is a frequent reason for seeking medical care but few prescription options are available. Lozenges are effective in delivering active ingredients to the throat. This study was conducted to determine the analgesic efficacy of two lozenges one containing amylmetacresol (AMC)/2,4-dichlorobenzyl alcohol (DCBA) and lidocaine and one containing hexylresorcinol  versus placebo in patients with acute sore throat due to upper respiratory tract infection (URTI). This was a multicentre, randomised, double-blind, parallel group, placebo-controlled study. In total, 190 patients were randomised 1:1:1 to a single dose of AMC/DCBA + lidocaine, hexylresorcinol or placebo lozenge. Subjective ratings of throat soreness, difficulty swallowing, swollen throat, numbing, and sore throat relief were obtained up to 2 hours post dose. Patient and investigator global ratings and a consumer questionnaire were also collected. The primary endpoint was the change from baseline in severity of throat soreness for both lozenges versus placebo at 2 hours post dose. The hexylresorcinol lozenge demonstrated superiority over placebo for primary and secondary efficacy variables including those related to throat soreness, sore throat relief and difficult...Continue Reading

Citations

Jul 12, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Nilufar FoadiJörg Ahrens
Sep 21, 2017·Medicines·Sabrina MacéH P Vasantha Rupasinghe
Apr 17, 2020·Pain Management·Bernard SchachtelAdrian Shephard
Nov 22, 2013·Journal of Anesthesia·Gözde Bumin AydınFatma Kavak Akelma
Sep 5, 2017·International Journal of Clinical Practice·Gesine WeckmannJean-François Chenot
Aug 23, 2016·Maxillofacial Plastic and Reconstructive Surgery·Yei-Jin KangSeong-Gon Kim
Jan 10, 2014·Archives of Dermatological Research·Yen-Kim WonMichael D Southall

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