PMID: 9186385Jun 7, 1997Paper

Randomised feasibility trial of pre-exposure rabies vaccination with DTP-IPV in infants

Lancet
J LangS A Plotkin

Abstract

Pre-exposure vaccination against rabies generally simplifies treatment and could be especially beneficial to children in countries where the disease is enzootic. We studied the feasibility of administering to infants pre-exposure rabies vaccination with combined diphtheria, tetanus, whole-cell pertussis, and inactivated poliomyelitis vaccine (DTP-IPV). 84 Vietnamese infants were randomly assigned to groups that received three doses of DTP-IPV vaccine at 2, 3, and 4 months of age alone (n = 43) or with two doses of purified Vero cell rabies vaccine (PVRV) at 2 and 4 months (n = 41). The safety and immunogenicity data of the groups were compared. All infants in both groups developed protective antibody concentrations against diphtheria, tetanus, pertussis, and polio. All infants who received the PVRV vaccine developed protective antibody concentrations against rabies. No serious adverse effects were reported, nor did systemic reactions differ between groups. Administration of PVRV with DTP-IPV proved safe, and elicited what are presumed to be protective antibody concentrations to all antigens in all 41 infants. Confirmation of these results could lead to integration of pre-exposure rabies vaccination into Expanded Programme on Im...Continue Reading

References

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Citations

Nov 7, 2007·Travel Medicine and Infectious Disease·Franco Giovanetti
Jul 24, 2007·The Journal of Pediatrics·Thavatchai KamolthamClaudius Malerczyk
Sep 20, 2015·Infectious Disease Clinics of North America·Rodney E Willoughby
Oct 7, 2010·Expert Review of Vaccines·James P McGettigan
Oct 21, 2004·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mark A FletcherPierre Saliou
Apr 11, 2013·Human Vaccines & Immunotherapeutics·Claudius MalerczykWolfgang Bender
Jan 18, 2014·Vaccine·Betty DodetHelen Rees
Nov 7, 2007·Travel Medicine and Infectious Disease·Stephen Toovey
Mar 3, 2017·Bulletin of the World Health Organization·Jocelyn A KesselsDeborah Briggs
Jun 5, 2002·Journal of Travel Medicine·William M Stauffer, Deepak Kamat

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