Randomised placebo-controlled trial of human recombinant insulin-like growth factor I plus intensive insulin therapy in adolescents with insulin-dependent diabetes mellitus

Lancet
C L AceriniD Dunger

Abstract

Good glycaemic control in insulin-dependent diabetes mellitus (IDDM) to prevent complications may be difficult to achieve during adolescence, because abnormalities in production of growth hormone or insulin-like growth-factor-I (IGF-I) can lead to lower insulin sensitivity. Recombinant human IGF-I (rhIGF-I) given as an adjunct to insulin therapy in IDDM, might improve glycaemic control in adolescents; we investigated the effects of the addition of IGF-I in a randomised, double-blind, placebo-controlled trial. 53 patients with IDDM (26 male, 27 female) with a median age of 16.1 years (range 10.8-20.6) and diabetes of more than 2 years' duration were randomly assigned subcutaneous rhIGF-I (20 or 40 microg/kg daily [n=18, n=18, respectively]) or placebo (n=17), both in addition to multiple-injection insulin therapy for 24 weeks. The primary endpoint, glycated haemoglobin (HbA1c) and routine biochemistry were measured every 4 weeks. Retinal photographs and glomerular-filtration rates were assessed at base line and at the end of the study. Data were analysed by intention to treat. With a dose of 40 microg/kg rhIGF-I daily, we found significant reductions in HbA1c compared with placebo (p=0.03), without changes in body-mass index, ra...Continue Reading

References

Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·J A EdgeC P Smith
Sep 1, 1983·The New England Journal of Medicine·T J MerimeeE R Froesch
Aug 9, 1984·The New England Journal of Medicine·UNKNOWN Kroc Collaborative Study Group
Mar 29, 1984·The New England Journal of Medicine·J E Gerich
Jun 1, 1982·Archives of Disease in Childhood·N P Mann, D I Johnston
Oct 1, 1994·The Journal of Clinical Endocrinology and Metabolism·M A BachC A Bondy
Jun 1, 1995·Archives of Disease in Childhood·D B Dunger
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Oct 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·T D CheethamD B Dunger

❮ Previous
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Citations

Jul 21, 2012·Current Diabetes Reports·Subhadra C Gunawardana
Aug 7, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jun Ren
Sep 15, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·H L SimpsonD L Russell-Jones
Jan 29, 2000·Clinical Endocrinology·J A Janssen, S W Lamberts
Feb 28, 2001·Diabetes, Obesity & Metabolism·C L Acerini, D B Dunger
Jan 10, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·R I G HoltP H Sönksen
Jun 27, 2000·Australian and New Zealand Journal of Medicine·L A Bach
Feb 14, 2008·Diabetes, Obesity & Metabolism·Vivienne A EzzatMark T Kearney
Jun 12, 1998·Archives of Disease in Childhood·J P Shield, J D Baum
May 12, 2005·Hormone Research·Robert J FerryLorraine E Levitt Katz
Jul 11, 2009·Endocrine Reviews·Claes OhlssonJohan Svensson
Apr 19, 2005·Treatments in Endocrinology·Vidya Mohamed-Ali, Jonathan Pinkney
Oct 30, 2004·Treatments in Endocrinology·Craig A JefferiesDenis Daneman
Feb 24, 2006·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Anna C Calkin, Terri J Allen
Mar 16, 2004·Pediatric Diabetes·C Giusti
Oct 27, 1999·Canadian Journal of Physiology and Pharmacology·P Murzenok, V Goranov
Mar 21, 2006·Annals of Biomedical Engineering·Julie M D Paye, Kimberly Forsten-Williams
Aug 20, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Namrata Ajaykumar Desai, Snehal S Patel
Feb 11, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Nelly Mauras, Morey W Haymond
Jul 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Martin O SavageDavid B Dunger
Aug 15, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·U BergP Bang
Apr 25, 2006·Journal of Diabetes and Its Complications·Gail M SeigelDouglas N Ishii
Aug 31, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M O SavageR G Rosenfeld
Aug 22, 2015·Current Diabetes Reports·Rebecca Schechter, Sirimon Reutrakul
Feb 3, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·T T L Pang, P Narendran
Jan 20, 2011·Clinical Science·Elena ContiMassimo Volpe
Dec 3, 2013·Expert Opinion on Pharmacotherapy·Johnny Ludvigsson
Mar 28, 2008·Expert Opinion on Drug Metabolism & Toxicology·Rachel M WilliamsDavid B Dunger
Feb 7, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·B FeldmannB O Boehm
Sep 17, 2008·Expert Review of Cardiovascular Therapy·Afroze AbbasMark T Kearney
Nov 18, 2009·Expert Opinion on Biological Therapy·G N Ajay ThankamonyCarlo L Acerini
Apr 30, 2005·Trends in Endocrinology and Metabolism : TEM·Michael B Ranke
Aug 21, 2002·Circulation·Jan FrystykHans Orskov

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