Randomised revaccination with pneumococcal polysaccharide or conjugate vaccine in asplenic children previously vaccinated with polysaccharide vaccine

Vaccine
F SmetsE Sokal

Abstract

Asplenic children are at high risk of invasive pneumococcal infection. In this group, the American Academy of Pediatrics recommends a single revaccination with the 23-valent polysaccharide vaccine (PSV23) 3-5 years after a previous PSV23 dose. Despite potential advantages, there are few data available regarding the safety and immunogenicity of the heptavalent pneumococcal conjugate vaccine (PCV7) in this population. The aim of the study was to prospectively determine and to compare, in asplenic children, the vaccine specific antibody titres against the seven serotypes included in the PCV7 after administration of one dose of PCV7 or of PSV23, 3 years or more after an initial vaccination with PSV23. In this randomised, single-centre study, antibody titres were monitored at baseline, at 1 and 6 months after revaccination in 21 children with anatomic or functional asplenia. Response was considered as positive when there was a four-fold increase in antibody titres from baseline. The most frequently reported adverse events were local reactions in 7/11 of PCV7 subjects and in 5/8 of PSV23 subjects, and general reactions (loss of appetite, sleepiness) in 5/11 of PCV7 subjects and in 1/8 of PSV23 subjects; without any serious adverse ev...Continue Reading

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Citations

Jun 2, 2015·Pakistan Journal of Biological Sciences : PJBS·Abdolreza Sotoodeh JahromiAbdolhossien Madani
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay RamPeter A Rice
Dec 25, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A Meerveld-EgginkG T Rijkers
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Jun 18, 2015·Expert Review of Vaccines·Mark A FletcherNathalie Dartois
Jul 31, 2013·Expert Opinion on Biological Therapy·Ruth MitchellAndrew J Pollard
Apr 19, 2017·Pediatric Research·Pei-Lan ShaoShuenn-Nan Chiu
Aug 8, 2018·BMC Infectious Diseases·Helene A S IngelsHans-Christian Slotved
Sep 17, 2020·JAMA Surgery·Fabio CascianiCharles M Vollmer
Jul 3, 2021·Human Vaccines & Immunotherapeutics·Kenichi TakeshitaNaoki Shimojo

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