Randomised revaccination with pneumococcal polysaccharide or conjugate vaccine in asplenic children previously vaccinated with polysaccharide vaccine

F SmetsE Sokal


Asplenic children are at high risk of invasive pneumococcal infection. In this group, the American Academy of Pediatrics recommends a single revaccination with the 23-valent polysaccharide vaccine (PSV23) 3-5 years after a previous PSV23 dose. Despite potential advantages, there are few data available regarding the safety and immunogenicity of the heptavalent pneumococcal conjugate vaccine (PCV7) in this population. The aim of the study was to prospectively determine and to compare, in asplenic children, the vaccine specific antibody titres against the seven serotypes included in the PCV7 after administration of one dose of PCV7 or of PSV23, 3 years or more after an initial vaccination with PSV23. In this randomised, single-centre study, antibody titres were monitored at baseline, at 1 and 6 months after revaccination in 21 children with anatomic or functional asplenia. Response was considered as positive when there was a four-fold increase in antibody titres from baseline. The most frequently reported adverse events were local reactions in 7/11 of PCV7 subjects and in 5/8 of PSV23 subjects, and general reactions (loss of appetite, sleepiness) in 5/11 of PCV7 subjects and in 1/8 of PSV23 subjects; without any serious adverse ev...Continue Reading


Jan 1, 1989·The Pediatric Infectious Disease Journal·G R SiberD V Madore
Mar 1, 1981·Reviews of Infectious Diseases·S H Landesman, G Schiffman
May 15, 2002·The Pediatric Infectious Disease Journal·Henry ShinefieldEdwin Lewis
Jun 22, 2002·The Pediatric Infectious Disease Journal·Gordon E SchutzeSheldon L Kaplan
Jun 29, 2002·Archives of Disease in Childhood·A FinnP Heath
Jul 3, 2003·Pediatrics·Sharon NachmanUNKNOWN Pediatric AIDS Clinical Trials Group Study 292 Team
Feb 21, 2006·British Journal of Haematology·Gerhard A StoehrStefan Zielen

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