PMID: 9164314May 17, 1997Paper

Randomised trial of addition of lamivudine or lamivudine plus loviride to zidovudine-containing regimens for patients with HIV-1 infection: the CAESAR trial

Lancet

Abstract

Previous studies have shown that combination therapy with lamivudine plus zidovudine causes pronounced and sustained increases in CD4 counts and reductions in viral load in individuals infected with HIV-1. We assessed the clinical benefit of the addition of lamivudine to zidovudine-based regimens in patients infected with HIV-1 who had CD4 counts of 25-250/microL. Eligible patients receiving zidovudine monotherapy or zidovudine plus zalcitabine or didanosine combination therapy were assigned 52 weeks of treatment with the addition of placebo, lamivudine (150 mg twice a day), or lamivudine (150 mg twice a day) plus loviride (100 mg three times a day). Patients were unaware of type of treatment allocated. The primary endpoint was progression to a new protocol-defined AIDS event or death. The study was terminated following the second interim analysis because of a highly significant reduction in progression to AIDS or death in the patients treated with lamivudine rather than placebo. In the final analysis of 1840 patients, progression had occurred in 95 (20%) of 471 placebo-treated patients, 86 (9%) of 907 lamivudine-treated patients, and 42 (9%) of 462 patients who received lamivudine plus loviride (p < 0.0001, relative hazard 0.4...Continue Reading

References

Apr 23, 1994·BMJ : British Medical Journal·J D LundgrenJ O Nielsen

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Citations

Jul 31, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·S J van HalD Marriott
Jan 19, 2000·Public Health·D DaviesC Camilleri-Ferrante
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·S Forsythe, C Gilks
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