PMID: 9536833Apr 16, 1998Paper

Randomised trial of erythromycin on the development of chronic lung disease in preterm infants

Archives of Disease in Childhood. Fetal and Neonatal Edition
A LyonP Ross

Abstract

To determine if erythromycin given from birth reduces the inflammatory response and the incidence and severity of chronic lung disease. Seventy five infants less than 30 weeks of gestation and ventilated from birth for lung disease were randomly assigned to receive erythromycin intravenously for 7 days or to no treatment. Ureaplasma urealyticum was detected in tracheal secretions by culture and polymerase chain reaction. Differential cell counts were obtained from bronchoalveolar lavage fluid collected daily for 5 days and concentrations of the cytokines interleukins IL-1 beta and IL-8, and tumour necrosis factor alpha (TNF-alpha) were measured. Chronic lung disease (CLD) was defined as oxygen dependency at 36 weeks of gestation. Nine infants (13%) were positive for U urealyticum. The inflammatory cytokines in the lungs increased over the first 5 days of life in all babies, but no association was found between their concentrations and the development of CLD. Those treated with erythromycin showed no significant differences from the non-treated group in the differential cell counts or concentrations of the cytokines. The two groups had a similar incidence of CLD. Babies infected with U urealyticum did not have a more pronounced ...Continue Reading

References

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Citations

Dec 24, 2005·The Pediatric Infectious Disease Journal·Robert L SchelonkaDaniel K Benjamin
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