PMID: 6398725Dec 1, 1984Paper

Randomised trial of mesterolone versus vitamin C for male infertility. Scottish Infertility Group

British Journal of Urology
T B HargreaveR A Elton

Abstract

A prospective randomised trial was carried out to assess the effect of 9 months' treatment with either mesterolone or vitamin C in 368 men complaining of an infertile marriage. There was no significant difference in the wife's pregnancy rate between the two treatment groups. A separate analysis of the data was made to include only men with a low normal testosterone (less than 16 nmol/l) and low sperm density (less than 10 million/ml). This separate analysis was also restricted to men married to wives with normal test results for tubal patency and ovulation and again there was no difference in pregnancy rates between the two treatment groups. These results indicate that mesterolone therapy given in the absence of any defined endocrinopathy is of no benefit in promoting male fertility and furthermore we have been unable to find any subgroup who will respond. Improvements in the therapy of male infertility are only likely after a diagnosis has been defined.

References

Jan 1, 1978·International Urology and Nephrology·J SzöllösiM Sas
May 1, 1977·Clinical Endocrinology·F R JackamanG D Chisholm
Nov 1, 1972·Computer Programs in Biomedicine·E T Lee, M M Desu
Dec 1, 1983·British Journal of Urology·T B Hargreave, R A Elton
Dec 1, 1982·British Journal of Urology·B J AbelA Yates
Jun 1, 1980·International Journal of Andrology·R Eliasson, K Dornbusch

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Citations

Jan 28, 1999·Molecular and Cellular Endocrinology·T B HargreaveH Cooke
Jun 21, 2011·Asian Journal of Andrology·Francesco LombardoAndrea Lenzi
Dec 15, 2000·International Journal of Andrology·D A Adamopoulos
Jul 1, 1996·International Journal of Urology : Official Journal of the Japanese Urological Association·M Namiki
Nov 1, 1993·British Journal of Obstetrics and Gynaecology·P VandekerckhoveT W Harada
Oct 2, 2009·Journal of Clinical Biochemistry and Nutrition·Abasalt H Colagar, Eisa T Marzony
Jan 16, 2016·International Journal of Molecular Sciences·Chun-Hou LiaoYing-Hung Lin
Apr 1, 1986·British Journal of Urology·T B HargreaveR A Elton
Apr 1, 1986·British Journal of Urology·T B Hargreave, R A Elton
Mar 1, 1988·The Journal of Pharmacy and Pharmacology·A L Gadd, P B Curtis-Prior
Jul 20, 2007·The Cochrane Database of Systematic Reviews·P VandekerckhoveE Hughes
Jan 9, 2003·The Urologic Clinics of North America·Farjaad M Siddiq, Mark Sigman
Jun 1, 2004·Reproductive Biomedicine Online·Ashok AgarwalTamer M Said

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