PMID: 7526098Nov 12, 1994Paper

Randomised trial of thiacetazone and rifampicin-containing regimens for pulmonary tuberculosis in HIV-infected Ugandans. The Makerere University-Case Western University Research Collaboration

Lancet
A OkweraJ J Ellner

Abstract

Among HIV-positive patients who received treatment for active tuberculosis, thiacetazone has been associated with cutaneous hypersensitivity and recurrent tuberculosis. No controlled trials have investigated the safety and efficacy of thiacetazone-containing regimens compared with alternative regimens among patients with HIV. In a randomised clinical trial of 191 HIV-positive patients with active pulmonary tuberculosis, we examined the safety and short-term efficacy of isoniazid, rifampicin, and pyrazinamide for two months followed by isoniazid and rifampicin for seven months (RHZ) compared with streptomycin, thiacetazone, and isoniazid for two months followed by thiacetazone and isoniazid for ten months (STH). Between May, 1990, and September, 1991, 191 HIV-positive adult Ugandan patients with acid-fast bacilli sputum smear-positive pulmonary tuberculosis (93% confirmed by culture) received either STH or RHZ. Subjects had a standard evaluation that included Mantoux skin test, complete blood count with differential white blood cell count, and chest radiography. After starting therapy, subjects were followed-up over one year for three outcomes: complications of anti-tuberculosis therapy, early sterilisation of cultures, and surv...Continue Reading

References

Dec 1, 1979·Chest·D A Mitchison
Jan 31, 1991·The New England Journal of Medicine·P M SmallP C Hopewell
Jan 1, 1991·The American Review of Respiratory Disease·P P ErikiT M Daniel
Jan 1, 1986·Social Science & Medicine·H N Barnum
Sep 1, 1988·Journal of the American Academy of Dermatology·S K HiraP L Perine
Jan 1, 1969·Respiration; International Review of Thoracic Diseases·H A Van Geuns
Aug 1, 1993·Annals of Internal Medicine·S MorenoD López-Gay
Jun 10, 1993·The New England Journal of Medicine·S A CoopmanR S Stern

❮ Previous
Next ❯

Citations

May 15, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·S Rajasekaran, Gaurav Khandelwal
Feb 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·J BruchfeldL Lindquist
Sep 7, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·C Kang'ombeP Nunn
Mar 24, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·A BanerjeeA Harries
Dec 23, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·A D HarriesP Nunn
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·P M KellyJ M Kaldor
Feb 16, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·A D HarriesF M Salaniponi
Sep 19, 2003·Lancet·Thomas R FriedenChristopher Dye
Feb 14, 2004·Lancet·Joia S MukherjeeKwonjune J Seung
Oct 21, 1995·Lancet·A M ElliottS D Foster
Jan 1, 1997·Pharmacology & Therapeutics·A D Harries
Sep 29, 2011·HIV Medicine·A L PozniakUNKNOWN BHIVA Guidelines Subcommittee
May 5, 2010·Antimicrobial Agents and Chemotherapy·Jotam G Pasipanodya, Tawanda Gumbo
Apr 13, 2011·Clinical Microbiology Reviews·Candice K Kwan, Joel D Ernst
Apr 25, 2000·Postgraduate Medical Journal·A ZumlaJ M Grange
Dec 2, 2011·Journal of Pregnancy·Olabisi M Loto, Ibraheem Awowole
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·J MurrayP Godfrey-Faussett
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·W J Burman, B E Jones
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Henry M BlumbergUNKNOWN American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society
Sep 21, 2006·Respiratory Research·Lisa Claire du ToitMichael Paul Danckwerts
Jan 7, 2011·PloS One·Masja StraetemansMarieke J van der Werf
Jul 9, 2011·PloS One·Masja StraetemansMarieke J van der Werf
Jul 28, 2005·Tropical Medicine & International Health : TM & IH·Dermot MaherHaileyesus Getahun
Mar 7, 2014·Expert Opinion on Drug Metabolism & Toxicology·Jonathan Reynolds, Scott K Heysell
Nov 10, 2016·Expert Review of Clinical Pharmacology·Eric F EgelundCharles A Peloquin
Dec 5, 2008·Expert Review of Anti-infective Therapy·Andrea T Cruz, Jeffrey R Starke
Jan 11, 2008·Journal of Perinatal Medicine·Oriol CollYves Ville
Aug 17, 2006·The Annals of Pharmacotherapy·Daren LinMichael J Rieder
Sep 14, 2016·Biomédica : revista del Instituto Nacional de Salud·Johanna OsorioEsperanza García
Aug 16, 2006·American Journal of Respiratory and Critical Care Medicine·Kwok C ChangCheuk M Tam
Oct 3, 2006·Expert Review of Anti-infective Therapy·Stephen J Rogerson, Clara Menendez
Mar 12, 2004·Clinical and Diagnostic Laboratory Immunology·Sandeep MukherjeeAntonio Campos-Neto
Dec 24, 2010·American Journal of Respiratory and Critical Care Medicine·Asha AnandaiahNaimish R Patel
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kamal DuaPhilip M Hansbro
Mar 29, 2002·Infectious Disease Clinics of North America·J Peter CegielskiMario C Raviglione
Mar 30, 2000·Infectious Disease Clinics of North America·P CahnG Prada-Trujillo
Oct 1, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Weerawat ManosuthiSomnuek Sungkanuparph
Oct 12, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·UNKNOWN Joint Task Force on Practice ParametersUNKNOWN Joint Council of Allergy, Asthma and Immunology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.