Randomised Trial of Two Different Daily Doses of Interferon-α versus Classical Therapy in Treatment-Naïve Patients with Chronic Hepatitis C

Clinical Drug Investigation
G MontaltoR Siciliano

Abstract

To evaluate the efficacy and tolerability of two different daily doses of interferon-α (lymphoblastoid-IFNα-N1, Wellferon®) [IFNα] for 2 months, followed by the same dose on alternate days for up to 1 year, versus administration on alternate days for 1 year. A non-blind, randomised study of outpatients with chronic hepatitis C at five centres in Sicily, Italy. Ninety-seven consecutive treatment-naive patients [72 patients with hepatitis C virus (HCV) genotype 1b infection] with histological chronic hepatitis C were included in the study and randomised to receive IFNα subcutaneously: 5 million international units (MIU) daily for 2 months, followed by the same dose on alternate days for up to 1 year (n = 33, group A); 3 MIU for 2 months, followed by the same dose on alternate days for up to 1 year (32, group B); 5 MIU on alternate days for 12 months (32, group C). Adverse effects were monitored through interviews and by clinical and biochemical check-ups at 1-month intervals. There were no significant differences between the three groups with regard to age, gender, HCV genotype distribution, or severity of histological findings. Seven patients dropped out of the study because of severe adverse effects: three from group A, two fro...Continue Reading

References

Jan 1, 1994·Journal of Clinical Microbiology·M PistelloM Tuoni
Aug 1, 1993·Journal of Interferon Research·O BeloquiM P Civeira
Oct 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T PoynardJ P Zarski
Jan 30, 1997·The New England Journal of Medicine·J H Hoofnagle, A M di Bisceglie
Jul 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N P LamT J Layden
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S ZeuzemW K Roth
Dec 7, 2000·The New England Journal of Medicine·E J HeathcoteJ De Pamphilis

❮ Previous
Next ❯

Citations

Dec 1, 2007·European Journal of Gastroenterology & Hepatology·Lydia GiannitrapaniGiuseppe Montalto
Jun 11, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Keryn J ChristiansenCheryll A McCullough
Mar 16, 2013·The Journal of Pharmacy and Pharmacology·Kai YueXiao Lin
Oct 13, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·M SoresiG Montalto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Hideyuki NomuraHiromi Ishibashi
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M PardoV Carreño
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
S HuraibA Abdulla
© 2022 Meta ULC. All rights reserved