Abstract
To check the hypothesis that continuous magnesium infusion protects the heart from arrhythmias following cardiopulmonary bypass surgery for congenital heart disease. A prospective randomised placebo-controlled study, with patients stratified in three weight groups. The study group ( n=65) postoperatively received a magnesium infusion (1 mmol/kg), the control group ( n=66) received placebo. In both groups serum and ionised magnesium values were followed, and all postoperative arrhythmias were documented for 24 h. Serum and ionised magnesium in the blood was elevated after the end of bypass (0.54+/-0.15 mmol l(-1) pre-operatively, 0.88+/-0.24 mmol l(-1) postoperatively), where a cardioplegia solution containing magnesium was used. Magnesium values remained at this elevated level in the magnesium therapy group, and decreased to normal pre-operative values within 24 h in controls ( P<0.001). The incidence of postoperative arrhythmias was lower in the study group: 8/65 in the study group and 17/66 in the control group, respectively (chi-squared test, P=0.05). Lower patient weight (32.7 kg versus 22.6 kg), longer cardiopulmonary bypass time (128.7 min versus 87.9 min) and deeper body temperature during extracorporeal circulation (29....Continue Reading
Citations
Jan 16, 2008·Intensive Care Medicine·J B AndreasenH B Ravn
Feb 28, 2013·Pediatric Cardiology·Hee Young LeeEun Young Kim
Dec 6, 2005·Pediatric Research·Dominique BiarentMarc Leeman
Nov 23, 2006·Intensive Care Medicine·Sylvie Di FilippoRicardo Muñoz
Oct 13, 2009·The Journal of Thoracic and Cardiovascular Surgery·Ana M ManriqueRicardo Munoz
May 31, 2006·The Journal of Thoracic and Cardiovascular Surgery·Jeffrey W DelaneyChristopher S Snyder
Mar 22, 2005·Archives of Medical Research·Roderich E Schwarz, Kathryn Z Nevarez
Apr 12, 2016·The Journal of Physical Chemistry. B·Srabani TaraphderGregory A Voth
Aug 7, 2010·Interactive Cardiovascular and Thoracic Surgery·Yashwant Singh VermaUsha Kiran
Sep 17, 2005·European Journal of Anaesthesiology·K SatohR Ogawa
Aug 27, 2005·European Journal of Anaesthesiology·K SatohA Matsuura
Aug 5, 2004·Intensive Care Medicine·Edward AbrahamBenoit Vallet
Jul 1, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kylie D LewisBodil M K Larsen
Jan 5, 2006·Pediatric Cardiology·A S BatraJ E Hubbard