Randomised trial on the influence of continuous magnesium infusion on arrhythmias following cardiopulmonary bypass surgery for congenital heart disease

Intensive Care Medicine
S DittrichP E Lange

Abstract

To check the hypothesis that continuous magnesium infusion protects the heart from arrhythmias following cardiopulmonary bypass surgery for congenital heart disease. A prospective randomised placebo-controlled study, with patients stratified in three weight groups. The study group ( n=65) postoperatively received a magnesium infusion (1 mmol/kg), the control group ( n=66) received placebo. In both groups serum and ionised magnesium values were followed, and all postoperative arrhythmias were documented for 24 h. Serum and ionised magnesium in the blood was elevated after the end of bypass (0.54+/-0.15 mmol l(-1) pre-operatively, 0.88+/-0.24 mmol l(-1) postoperatively), where a cardioplegia solution containing magnesium was used. Magnesium values remained at this elevated level in the magnesium therapy group, and decreased to normal pre-operative values within 24 h in controls ( P<0.001). The incidence of postoperative arrhythmias was lower in the study group: 8/65 in the study group and 17/66 in the control group, respectively (chi-squared test, P=0.05). Lower patient weight (32.7 kg versus 22.6 kg), longer cardiopulmonary bypass time (128.7 min versus 87.9 min) and deeper body temperature during extracorporeal circulation (29....Continue Reading

Associated Clinical Trials

Citations

Jan 16, 2008·Intensive Care Medicine·J B AndreasenH B Ravn
Nov 23, 2006·Intensive Care Medicine·Sylvie Di FilippoRicardo Muñoz
May 31, 2006·The Journal of Thoracic and Cardiovascular Surgery·Jeffrey W DelaneyChristopher S Snyder
Mar 22, 2005·Archives of Medical Research·Roderich E Schwarz, Kathryn Z Nevarez
Apr 12, 2016·The Journal of Physical Chemistry. B·Srabani TaraphderGregory A Voth
Aug 7, 2010·Interactive Cardiovascular and Thoracic Surgery·Yashwant Singh VermaUsha Kiran
Sep 17, 2005·European Journal of Anaesthesiology·K SatohR Ogawa
Jul 1, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kylie D LewisBodil M K Larsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.