Abstract
We evaluated the survival benefit, safety, feasibility, and tolerability of dose-dense (DD) adjuvant chemotherapy with epirubicin and paclitaxel for women with node-positive primary breast cancer. Randomised patients (n=216) received DD or conventional-schedule (CS) chemotherapy. Dose-dense regimen patients (n=108) received epirubicin 90 mg m-2 plus paclitaxel 175 mg m-2 in four 14-day cycles, then cyclophosphamide 600 mg m-2, methotrexate 40 mg m-2, and fluorouracil 600 mg m-2 (CMF 600/40/600) in three 14-day cycles, plus filgrastim 5 microg kg day-1 as growth support in every cycle. Conventional-schedule regimen patients (n=108) received epirubicin 90 mg m-2 plus cyclophosphamide 600 mg m-2 in four 21-day cycles, then CMF 600/40/600 in three 21-day cycles, plus filgrastim if required. After a median follow-up of 38.4 months, 71 patients (33%) relapsed or died: DD, 33 patients (15 deaths); CS, 38 patients (22 deaths). Dose dense showed a trend for improved disease-free survival (DFS) and overall survival (OS). Four-year rates of DFS and OS were 64 and 85% for DD, and 58 and 75% for CS. All seven cycles were administered to 208 patients (96%). Rates of cycle delay, discontinuation, dose reduction, and adverse events were simila...Continue Reading
References
Jan 1, 1977·British Journal of Cancer·R PetoP G Smith
Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Apr 6, 1995·The New England Journal of Medicine·G BonadonnaC Brambilla
May 5, 1994·The New England Journal of Medicine·W C WoodC R Ferree
Feb 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Bonadonna
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M N LevineD Tu
Aug 27, 1998·Journal of the National Cancer Institute·D R BudmanE Frei
Oct 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H OzerUNKNOWN American Society of Clinical Oncology
Dec 18, 2001·Cancer·B K LinkUNKNOWN Oncology Practice Pattern Study Working Group
Jan 16, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·S Glück
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre FumoleauElisabeth Luporsi
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I Craig HendersonLarry Norton
Apr 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc L CitronLarry Norton
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jacques BonneterreIsabelle Chapelle-Marcillac
Jun 3, 2005·The New England Journal of Medicine·Miguel MartinUNKNOWN Breast Cancer International Research Group 001 Investigators
Citations
Dec 13, 2006·Future Oncology·Riccardo RicottaSalvatore Siena
Nov 26, 2010·Journal of the National Cancer Institute·Luisa BonillaSalomon M Stemmer
Feb 18, 2011·Radiation Oncology·Xinglei ShenMitchell Machtay
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey J KirshnerGary R Morrow
Nov 26, 2010·Journal of the National Cancer Institute·Pia Herbolsheimer, Sandra M Swain
Jul 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicole M KudererGary H Lyman
Jul 18, 2008·Supportive Cancer Therapy·Stephanie A GregoryFrancois E Wilhelm
Dec 30, 2008·Critical Reviews in Oncology/hematology·Francesco CreaRomano Danesi
Feb 10, 2018·Breast Cancer Research and Treatment·Hadar GoldvaserEitan Amir
Jan 24, 2007·British Journal of Cancer·N HorieS Fushiki
Feb 13, 2013·International Journal of Cancer. Journal International Du Cancer·Frederik MarméAndreas Schneeweiss
Aug 2, 2017·American Journal of Clinical Oncology·Hiroko MachidaKoji Matsuo
Jan 16, 2007·Current Opinion in Obstetrics & Gynecology·Sherko KümmelPeter Schmid
Mar 18, 2008·Breast Cancer Research and Treatment·H WildiersR Paridaens
Sep 3, 2008·Nature Clinical Practice. Oncology·Linda Vahdat
Jul 22, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Jordi GinésMiguel A Casado
Aug 14, 2013·Asia-Pacific Journal of Clinical Oncology·Jessica Sandy, Stephen Della-Fiorentina
Sep 3, 2019·The Cochrane Database of Systematic Reviews·Melina L WillsonNicholas Wilcken
Oct 19, 2007·The Cochrane Database of Systematic Reviews·T FergusonA K Nowak
May 27, 2020·Cancer Medicine·Adam S KomorowskiRossanna C Pezo
Feb 15, 2013·Expert Review of Anticancer Therapy·Markus Joerger, Beat Thürlimann
Apr 2, 2020·British Journal of Cancer·Eva BlondeauxLucia Del Mastro
Jan 5, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Orit FreedmanMark Clemons
Mar 1, 2014·Oncology Nursing Forum·Ellen Catuiza Mullen
Feb 26, 2019·Breast Care·Fernando Kude de Almeida, Daniela Dornelles Rosa
Jul 19, 2019·Breast Care·Mattea ReinischSherko Kümmel
May 16, 2012·The Breast Journal·Soley Bayraktar, Banu Arun
Oct 31, 2020·Scientific Reports·Sang Yoon LeeDuk-Kyung Kim
Nov 26, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M S AaproUNKNOWN European Organisation for Research and Treatment of Cancer