PMID: 7538240May 1, 1995Paper

Randomized clinical trial comparing low power-slow heating versus high power-rapid heating noncontact neodymium:yttrium-aluminum-garnet laser regimens for the treatment of benign prostatic hyperplasia

Urology
E OrihuelaM Warren

Abstract

To evaluate and compare the safety and effectiveness of two noncontact laser regimens for the treatment of human benign prostatic hyperplasia (BPH), and to assess the impact of the spatial distribution of the laser-induced lesions on treatment outcome. This was a prospective, double-blind, randomized study that included 29 patients with BPH (both the patients and the study physician assistant in charge of the follow-up evaluation were blinded to the treatment rendered). The patients were randomized to receive either a 15 W for 180 s (15 patients) or 50 W for 60 s (14 patients) laser regimen (powers measured at the fiber tip). There were two study phases for each treatment group: the irradiated sites were not overlapping during the first phase (lesions 1.5 cm apart), and were overlapping during the second phase (lesion less than 1.0 cm apart). Morbidity was minimal in both groups. At 1 year of follow-up, there was significant improvement of the American Urological Association-7 symptom score, the peak urinary flow rate, and the postvoid residual in both treatment groups. These improvements were not statistically significantly different regardless of time or the phase of the study for the two treatment groups. There were 3 treatm...Continue Reading

References

Jun 1, 1992·British Journal of Urology·A J CostelloJ Burt
Jan 1, 1992·Lasers in Surgery and Medicine·D E JohnsonD M Cromeens
Jan 1, 1995·Lasers in Surgery and Medicine·M MotamediM M Warren
Oct 21, 1961·JAMA : the Journal of the American Medical Association·R D DRIPPSJ E ECKENHOFF

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