Randomized clinical trial comparing two one-week triple-therapy regimens for the eradication of Helicobacter pylori infection and duodenal ulcer healing

The American Journal of Gastroenterology
M FornéJ Garau

Abstract

One-week triple therapy has been shown to be effective in Helicobacter pylori eradication and duodenal ulcer healing. However, the optimal therapeutic combination has not yet been identified. Bismuth-containing regimens have the advantage of requiring only one antibiotic. It has been suggested that high doses of omeprazole improve the bactericidal efficacy of antimicrobial regimens against H. pylori. We evaluated the efficacy of two 1-wk triple-therapy regimens for H. pylori eradication and duodenal ulcer healing. On an intention-to-treat basis, 182 patients with H. pylori-associated duodenal ulcer were randomized. Group OCB patients (n = 91) were given omeprazole 40 mg b.i.d., clarithromycin 500 mg b.i.d., and colloidal bismuth subcitrate 120 mg q.i.d. for 7 days. Group OCA patients (n = 91) were treated with omeprazole and clarithromycin at the same doses plus amoxicillin 1 g b.i.d., also for 7 days. Endoscopies were performed at entry and at 4 wk after the end of treatment. The presence of H. pylori was assessed by urease test, histology, Gram stain, and culture. No patient received follow-up treatment. H. pylori eradication rates achieved in the OCB and OCA groups were similar whether by intention-to-treat (82.4% vs 88.9% ;...Continue Reading

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Citations

Mar 3, 2004·World Journal of Gastroenterology : WJG·Yuksel GumurduluSedat Boyacioglu
May 27, 2004·World Journal of Gastroenterology : WJG·Engin AltintasHandan Camdeviren
Jul 9, 2014·Nature Reviews. Gastroenterology & Hepatology·Peter MalfertheinerMichael Selgrad
Mar 2, 2005·The Journal of Small Animal Practice·A K BoagD J Connolly
Aug 2, 2000·Journal of Gastroenterology and Hepatology·Y TokunagaK Ohsumi
Nov 4, 2000·Journal of Gastroenterology and Hepatology·W H WangS K Lam
Aug 19, 2014·World Journal of Gastroenterology : WJG·Hafez FakheriReza Malekzadeh
Feb 20, 2007·Alimentary Pharmacology & Therapeutics·R KhuranaB D Gold
Oct 13, 1998·Alimentary Pharmacology & Therapeutics·G A PipkinJ R Wood
Jun 10, 2000·Alimentary Pharmacology & Therapeutics·A ZulloA F Attili
Aug 10, 2000·Alimentary Pharmacology & Therapeutics·K KihiraK Sugano

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