Randomized Clinical Trial investigating Self-Assembling Peptide P11-4 for Treatment of Early Occlusal Caries.

Scientific Reports
Dafina DoberdoliHrvoje Juric

Abstract

Non-invasive caries treatment is a major focus in modern dentistry. The present study was designed to evaluate the effectiveness of monomeric self-assembling peptide P11-4 (SAP P11-4) in combination with fluoride varnish or polymeric self-assembling peptide matrix (SAPM) in treatment of non-cavitated occlusal caries. Ninety children and adolescents were included in this randomized, gold-standard-controlled clinical trial. Test Group 1 received SAP P11-4 and twice fluoride varnish at baseline and Day 180, Test Group 2 received SAP P11-4 on baseline and twice weekly SAPM (home-application), and Control Group received fluoride varnish on baseline and Day 180. Caries progression was measured by laser fluorescence, Nyvad Caries Activity, ICDAS-II-codes, and investigator assessments. Laser fluorescence changes demonstrated superior results for Test Group 1 and 2, as values decreased compared to an increase for the Control Group (p < 0.0005). ICDAS-II codes at Day 360 showed partial regression for Test Group 1 (6.7%) and Test Group 2 (20.0%) and partial progression for Control Group (23.3%) (p < 0.01). Nyvad Caries Activity yielded superior caries inactivation for Test Groups, compared to Control Group (p = 0.002). This trial showed t...Continue Reading

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Citations

Sep 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shama S M DissanayakeMargaret A Brimble
Nov 21, 2020·Scientific Reports·Paulina Sedlakova KondelovaIvo Krejci
May 10, 2021·Advanced Drug Delivery Reviews·Christina Karavasili, Dimitrios G Fatouros
Jul 1, 2021·Critical Reviews in Biotechnology·Amanda Marchini, Fabrizio Gelain

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Methods Mentioned

BETA
Fluorescence

Clinical Trials Mentioned

NCT03780270

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