Randomized clinical trial of laparoscopic versus open donor nephrectomy

The British Journal of Surgery
M L NicholsonP S Veitch

Abstract

This randomized controlled trial was designed to determine the safety and efficacy of laparoscopic donor nephrectomy (LDN) in comparison with short-incision open donor nephrectomy (ODN). Eighty-four live kidney donors were randomized in a 2 : 1 ratio to LDN (56 patients) or short-incision ODN without rib resection (28). Primary endpoints were pain relief and duration of inpatient stay. There was no donor death or allograft thrombosis in either group. The first warm ischaemic time median (range) 4 (2-7) versus 2 (1-5) min; P = 0.001) and the duration of operation (160 (110-250) versus 150 (90-200); P = 0.004) were longer for LDN. LDN led to a reduction in parenteral morphine requirement 59 (6-136) versus 90 (35-312) mg; P = 0.001) and hospital stay (4 (2-6) versus 6 (2-9) days; P = 0.001), and earlier return to employment (42 (14-84) versus 66.5 (14-112) days; P = 0.004). Postoperative respiratory function was improved after LDN. There were more postoperative complications per donor in the ODN group (0.6(0.7) versus 0.3(0.5); P = 0.033). At a median follow-up of 74 months, there were no differences in renal function or allograft survival between the groups. LDN removes some of the disincentives to live donation without compromis...Continue Reading

References

Nov 1, 1991·British Journal of Anaesthesia·M K ReederD Smart
Oct 1, 1994·Journal of Endourology·D T ChangI S Sawczuk
Nov 14, 1997·Annals of Surgery·J L FlowersS T Bartlett
May 7, 2002·Urology·Shuin-Lin YangMarc A Greenstein
Jan 22, 2005·Clinical Transplantation·Joseph F BuellE Steve Woodle
Mar 30, 2005·BJU International·Nasser SimforooshSeyed M M Hosseini Moghaddam
Mar 30, 2006·Transplantation·Niels F M KokJan N M IJzermans

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Citations

Mar 1, 2011·Journal of Endourology·Helen R LeveyLouis R Kavoussi
Jun 30, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pankaj ChandakNizam Mamode
Dec 15, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark J Midwinter, Tom Woolley
Nov 15, 2012·Pain Research and Treatment·U Mathuram ThiyagarajanM L Nicholson
Aug 5, 2011·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Deepak DubeyG Srikanth
Feb 9, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Soichiro OgawaOsamu Yamaguchi
Oct 4, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Nasser SimforooshSeyed Amir Mohsen Ziaee
Feb 26, 2013·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ke WangZhen-li Gao
Jan 30, 2014·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Bulang HeJeffrey Hamdorf
Jan 24, 2014·Journal of Transplantation·Charlotte CrottyMichael L Nicholson
Sep 14, 2011·Transplantation Proceedings·E GorevskiJ Martin-Boone
Nov 9, 2016·Scandinavian Journal of Urology·Majken Højrup WiborgLars Lund
Dec 23, 2015·The Journal of International Medical Research·Hyun-Chang KimDeok Man Hong
Feb 11, 2011·Surgical Innovation·Jay NathAndrew R Ready
Jan 23, 2015·Journal of Hepato-biliary-pancreatic Sciences·Yasushi HasegawaGo Wakabayashi
Nov 9, 2011·Journal of the Korean Surgical Society·Volkan GencSelcuk Mevlut Hazinedaroglu
Oct 23, 2018·The British Journal of Surgery·M L NicholsonS A Hosgood
Apr 16, 2010·Prikladnaia biokhimiia i mikrobiologiia·R PrasannaC Natarajan
May 6, 2016·World Journal of Surgery·Julia B Kössler-EbsMarkus K Diener
Nov 11, 2011·The Cochrane Database of Systematic Reviews·Colin H WilsonNaeem A Soomro
Mar 26, 2014·ANZ Journal of Surgery·Shengqiang YuKe Wang
Jan 8, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Connie L Davis
Dec 19, 2019·Annals of the Royal College of Surgeons of England·T BrownA E Courtney
Feb 9, 2013·Surgical Endoscopy·Karel W J KlopFrank J M F Dor

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