Randomized clinical trial of skin closure by subcuticular suture or skin stapling after elective colorectal cancer surgery

The British Journal of Surgery
S KobayashiY Moriya

Abstract

The best suture method to prevent incisional surgical-site infection (SSI) after clean-contaminated surgery has not been clarified. Patients undergoing elective colorectal cancer surgery at one of 16 centres were randomized to receive either subcuticular sutures or skin stapling for skin closure. The primary endpoint was the rate of incisional SSI. Secondary endpoints of interest included time required for wound closure, incidence of wound problems, postoperative length of stay, wound aesthetics and patient satisfaction. A total of 1264 patients were enrolled. The cumulative incidence of incisional SSI by day 30 after surgery was similar after subcuticular sutures and stapled closure (8·7 versus 9·8 per cent respectively; P = 0·576). Comparison of cumulative incidence curves revealed that SSI occurred later in the subcuticular suture group (P = 0·019) (hazard ratio 0·66, 95 per cent c.i. 0·45 to 0·97). Wound problems (P = 0·484), wound aesthetics (P = 0·182) and postoperative duration of hospital stay (P = 0·510) did not differ between the groups; subcuticular sutures took 5 min longer than staples (P < 0·001). Patients in the subcuticular suture group were significantly more satisfied with their wound (52·4 per cent versus 42·...Continue Reading

References

Nov 1, 1992·The British Journal of Surgery·C J Ranaboldo, D C Rowe-Jones
Aug 1, 1985·The Australian and New Zealand Journal of Surgery·D Lubowski, D Hunt
Oct 1, 1993·Clinical Microbiology Reviews·T G Emori, R P Gaynes
Apr 29, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·A J MangramW R Jarvis
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Feb 24, 2001·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·M Delgado-RodríguezJ Llorca
Mar 10, 2001·Medical Care·A A HendriksJ C De Haes
Apr 11, 2001·Emerging Infectious Diseases·R L Nichols
Jul 11, 2006·The Journal of Hospital Infection·A JohnsonJ Reilly
Feb 6, 2007·Clinics in Dermatology·Jie LiRobert Kirsner
Dec 20, 2007·Plastic and Reconstructive Surgery·Adam J SingerJudd E Hollander
Dec 25, 2008·Annals of Surgery·Jensen T PoonOswens S H Lo
Jun 28, 1890·British Medical Journal·E Kingscote
Feb 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice B KornblithHyman B Muss
May 19, 2011·JAMA : the Journal of the American Medical Association·Jean-Paul GalmicheUNKNOWN LOTUS Trial Collaborators
Oct 1, 2013·Lancet·Toshimasa TsujinakaUNKNOWN Clinical Study Group of Osaka University on Section of Risk Management

❮ Previous
Next ❯

Citations

Oct 5, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kazuhiro ImamuraTetsuji Kaneko
Dec 12, 2018·Surgical Infections·David M Krpata
Apr 12, 2019·The British Journal of Surgery·Rebecca Grossman
Apr 10, 2020·The Cochrane Database of Systematic Reviews·Saori GotoYoshiharu Sakai
Sep 18, 2020·Journal of Plastic Surgery and Hand Surgery·F J L GasparK K Jensen
Apr 14, 2016·International Journal of Computer Assisted Radiology and Surgery·N SchochV Heuveline
Dec 26, 2018·Journal of Surgical Oncology·Francisco A Guzman-PrunedaCarl R Schmidt
Jun 23, 2020·Medicine·Giovanni CochettiEttore Mearini
Oct 27, 2020·World Journal of Surgery·Yoritaka MatsunoTadatoshi Takayama
Dec 16, 2020·Surgery Today·Hiroki OhgeUNKNOWN Committee for Gastroenterological Surgical Site Infection Guidelines, the Japan Society for Surgical Infection
Jul 19, 2019·Deutsches Ärzteblatt International·Elisabeth MaurerDetlef K Bartsch
Aug 12, 2021·The British Journal of Surgery·A SharmaL Best

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.