Randomized clinical trial of the effect of prenatal fluoride supplements in preventing dental caries

Caries Research
D H LeverettM E Moss

Abstract

This randomized, double-blind study tested the caries-preventive efficacy of prenatal fluoride supplementation in 798 children followed until age 5. Initially, 1,400 women in the first trimester of pregnancy residing in communities served by fluoride-deficient drinking water were randomly assigned to one of two groups. During the last 6 months of pregnancy the treatment group received 1 mg fluoride daily in the form of a tablet and the control group received a placebo. Both treatment and control subjects were encouraged to use postnatal dietary fluoride supplements. Caries was measured in children at age 3 and 5 while fluorosis was assessed at age 5. Caries activity was very low in both study groups: 92% of children remained caries-free in the treatment group and 91% remained caries-free in the placebo group. Fluorosis was observed in 26 subjects, all classified as very mild. Overall, there were no statistically significant differences in the study groups with respect to caries and fluorosis in deciduous teeth. The study had sufficient power to detect an absolute risk reduction of 5.1% while only a 1.5% reduction was observed. These findings do not support the hypothesis that prenatal fluoride has a strong caries-preventive eff...Continue Reading

Citations

Sep 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E H Goh, A W Neff
Jul 31, 2002·Community Dentistry and Oral Epidemiology·Steven M LevyMichael J Kanellis
Dec 8, 2000·Journal of Public Health Dentistry·N Tinanoff, C A Palmer
Oct 6, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Jumana B AmmariPaul F Ashley
Jul 22, 1998·Community Dentistry and Oral Epidemiology·A I Ismail
Apr 14, 2004·Journal of Public Health Dentistry·Liang HongBarbara Broffitt
Aug 18, 2006·Journal of Public Health Dentistry·Steven M LevyMichael J Kanellis
Apr 22, 2010·Community Dentistry and Oral Epidemiology·H Meyer-LueckelA Stang
Jan 17, 2014·Community Dentistry and Oral Epidemiology·Hyun-Jae ChoKwang-Hak Bae
Jul 18, 2006·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·J Opydo-Szymaczek, M Borysewicz-Lewicka
Nov 4, 2000·Pediatric Clinics of North America·T E Schafer, S M Adair
Jan 8, 2003·Journal of the American Dietetic Association·D FitzsimonsL D Boyd
Mar 23, 1999·The Journal of the American Dental Association·J J WarrenS M Levy
Nov 4, 2008·The Journal of the American Dental Association·Amid I Ismail, Hana Hasson
Aug 3, 2012·The Journal of the American Dental Association·Mark Donaldson, Jason H Goodchild
Dec 18, 2008·Journal of Applied Oral Science : Revista FOB·Régia Luzia ZanataPatrícia Silva Lopes Navarro
Jul 28, 2001·Journal of Public Health Dentistry·J J WarrenM J Kanellis
Nov 21, 2019·The Cochrane Database of Systematic Reviews·Elisha RiggsJudith C Gomersall
Jan 1, 2011·The Journal of Clinical Pediatric Dentistry·M EkambaramN M King
Jan 27, 2021·International Journal of Paediatric Dentistry·Robert J SchrothRena Sihra
Nov 20, 2002·Dental Clinics of North America·Erik ScheifeleNina Markovic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Dental Journal
S J Boyle, L Howells
Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners
L K Jonides
© 2021 Meta ULC. All rights reserved