Randomized clinical trial of topical tranexamic acid after reduction mammoplasty

The British Journal of Surgery
K AusenHilde Pleym

Abstract

The antifibrinolytic drug tranexamic acid is currently being rediscovered for both trauma and major surgery. Intravenous administration reduces the need for blood transfusion and blood loss by about one-third, but routine administration in surgery is not yet advocated owing to concerns regarding thromboembolic events. The aim of this study was to investigate whether topical application of tranexamic acid to a wound surface reduces postoperative bleeding. This was a randomized double-blind placebo-controlled trial on 30 consecutive women undergoing bilateral reduction mammoplasty. On one side the wound surfaces were moistened with 25 mg/ml tranexamic acid before closure, and placebo (saline) was used on the other side. Drain fluid production was measured for 24 h after surgery, and pain was measured after 3 and 24 h. Postoperative complications including infection, seroma, rebleeding and suture reactions were recorded. Topical application of tranexamic acid to the wound surface after reduction mammoplasty reduced drain fluid production by 39 per cent (median 12·5 (range 0-44) versus 20·5 (0-100) ml; P = 0·038). Adverse effects were not observed. There were no significant differences in postoperative pain scores or complications....Continue Reading

References

Sep 1, 1970·The Journal of Laryngology and Otology·H C Overbosch, H C Hart
Feb 1, 1995·Anesthesiology·J C HorrowJ L Parmet
Aug 2, 2002·Anesthesiology·Noreen P DowdJohn Butterworth
Nov 9, 2006·The Annals of Pharmacotherapy·Edna Patatanian, Susan E Fugate
Jan 11, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·I SarrisR A Kadir
Jan 19, 2008·American Journal of Rhinology·Theodore AthanasiadisPeter J Wormald
Feb 28, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Amir AbrishamiJean Wong
Sep 22, 2009·The Annals of Thoracic Surgery·James Barnard, Russell Millner
Feb 2, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Dumbor L Ngaage, John Martin Bland
Nov 5, 2010·The Journal of Bone and Joint Surgery. American Volume·Jean WongFrances Chung
Jan 5, 2011·Burns : Journal of the International Society for Burn Injuries·Jose P Sterling, David M Heimbach
Jan 21, 2011·The Cochrane Database of Systematic Reviews·David A HenryKatharine Ker
Oct 11, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Y M J TangP Brooks
Dec 29, 2011·The Annals of Pharmacotherapy·Heather J Ipema, Maria G Tanzi
May 23, 2012·BMJ : British Medical Journal·Katharine KerIan Roberts
Apr 2, 2013·The Journal of Arthroplasty·Tyler C WindJoseph T Moskal
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Christa A StojkovicSameena M Khan
Mar 19, 2014·The Journal of Arthroplasty·John R TuttleLee E Rubin
May 20, 2014·Burns : Journal of the International Society for Burn Injuries·Karl WalshBaljit Dheansa
Jun 27, 2014·Laryngo- rhino- otologie·D Hinder, K Tschopp
Aug 15, 2014·BMJ : British Medical Journal·Katharine Ker, Ian Roberts

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Citations

Apr 4, 2017·Anesthesia and Analgesia·A Lopez-PicadoBorja Barrachina
Apr 27, 2018·Plastic and Reconstructive Surgery·Alvaro Luiz CansancaoRafael A Vidigal
Sep 25, 2017·Plastic and Reconstructive Surgery·Rod J Rohrich, Min-Jeong Cho
Jul 10, 2020·Aesthetic Surgery Journal·Andrew L KochubaJames E Zins
May 26, 2018·Plastic and Reconstructive Surgery·Stav BrownPeter J Taub
Aug 3, 2020·Plastic and Reconstructive Surgery·Jason M WeisslerJorys Martinez-Jorge
Mar 17, 2020·The Breast Journal·Kush Raj LohaniAnita Dhar
Aug 20, 2019·Annales de chirurgie plastique et esthétique·S de Mortillet
Apr 18, 2021·Aesthetic Plastic Surgery·David A DaarPierre B Saadeh
Apr 29, 2021·Plastic and Reconstructive Surgery. Global Open·Esteban Elena Scarafoni
Jul 3, 2021·Aesthetic Surgery Journal. Open Forum·Nicolas M AbboudMarwan H Abboud
Sep 14, 2021·Facial Plastic Surgery & Aesthetic Medicine·Tania BenjaminRahul Seth

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Methods Mentioned

BETA
bilateral reduction
bilateral reduction mammoplasty

Software Mentioned

SPSS®

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