Randomized clinical trial to compare the efficacy to improve the quality of surgical field of hypotensive anesthesia with clonidine or dexmedetomidine during functional endoscopic sinus surgery

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Yolanda EscamillaCaridad Pontes

Abstract

Intense bleeding of the surgical field is a potential factor influencing success of functional endoscopic sinus surgery (FESS). Hypotensive anesthesia with α2 intravenous agonists reduces intraoperative bleeding, but which is the best agent is unknown. The main objective of this trial was to compare the current standard adjuvant drug for hypotensive anesthesia, clonidine, with the recently available alternative dexmedetomidine. A randomized clinical trial compared the efficacy of clonidine and dexmedetomidine during FESS. Treatment was open label for the anesthesiologist and operating surgeon, but blind for an external evaluator who evaluated video-recorded surgeries. A Boezaart scale was assessed every 30 min during FESS until surgery completion. Main end-point was the proportion of patients with mean Boezaart scores > 2 (heavy bleeding) by external blinded evaluator. Secondary end-points included other bleeding parameters, surgery duration, hemodynamic measures and surgical complications. 94 patients were randomized. There were no significant differences in the proportion of patients with mean Boezaart scores > 2 in clonidine (42.6%) and dexmedetomidine (42.6%). Consistently, no differences were observed in secondary variable...Continue Reading

References

May 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A P BoezaartA Coetzee
Oct 22, 2003·Acta otorrinolaringológica española·D R LoboC Górriz
Apr 6, 2004·The Laryngoscope·Andrew KaplanNeil Bhattacharyya
May 6, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kazuhiko OkuyamaHidenori Toyooka
May 4, 2006·British Journal of Anaesthesia·N M Elsharnouby, M M Elsharnouby
Jan 24, 2007·European Journal of Anaesthesiology·M DurmusM O Ersoy
Sep 7, 2007·Langenbeck's Archives of Surgery·Zahir F SoonawallaPeter J Friend
Sep 3, 2008·The British Journal of Surgery·H SeyednejadA M Seifalian
Apr 22, 2009·American Journal of Rhinology & Allergy·May ThwinPeter-John Wormald
Oct 21, 2009·Archives of Otolaryngology--head & Neck Surgery·Ali MoshaverIan J Witterick
Jun 8, 2010·Otolaryngologic Clinics of North America·Kevin C Welch, James A Stankiewicz
Sep 8, 2010·American Journal of Rhinology & Allergy·Silviu Albu, Roxana Lucaciu
Feb 4, 2011·Epidemiologic Perspectives & Innovations : EP+I·Joseph H Abramson
Oct 29, 2011·The Annals of Otology, Rhinology, and Laryngology·Damla Guclu GuvenAbdulkadir Iskender
Nov 17, 2011·The Laryngoscope·James A StankiewiczKevin Welch
Dec 25, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jarosław MiłońskiJurek Olszewski
Aug 21, 2013·The Annals of Otology, Rhinology, and Laryngology·Jungah LeeHyerim Kang
Sep 21, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A CardesínM Bernal-Sprekelsen
Jan 16, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·U SrivastavaA Gupta
Jun 9, 2016·Journal of Anaesthesiology, Clinical Pharmacology·Sukhminder Jit Singh BajwaAmarjit Singh
Jul 30, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Safinaz KarabayirliNebil Ark

❮ Previous
Next ❯

Citations

Aug 3, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Devalina GoswamiOngkila Bhutia
Sep 15, 2021·International Journal of Clinical Practice·Leyla KazanciogluSalim Neselioglu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Alda CardesínManuel Bernal-Sprekelsen
The Annals of Otology, Rhinology, and Laryngology
Damla Guclu GuvenAbdulkadir Iskender
© 2021 Meta ULC. All rights reserved