Randomized Comparison of Absorb Bioresorbable Vascular Scaffold and Mirage Microfiber Sirolimus-Eluting Scaffold Using Multimodality Imaging

JACC. Cardiovascular Interventions
Erhan TenekeciogluTeguh Santoso

Abstract

The primary objective of this study was to evaluate the safety and effectiveness of the Mirage (Manli Cardiology, Singapore) bioresorbable microfiber sirolimus-eluting scaffold compared with the Absorb (Abbott Vascular, Santa Clara, California) bioresorbable vascular scaffold in the treatment of stenotic target lesions located in native coronary arteries, ranging from ≥2.25 to ≤4.0 mm in diameter. Secondary objectives were to establish the medium-term safety, effectiveness, and performance of the Mirage device. The current generation of bioresorbable scaffolds has several limitations, such as thick square struts with large footprints that preclude their deep embedment into the vessel wall, resulting in protrusion into the lumen with microdisturbance of flow. The Mirage sirolimus-eluting bioresorbable microfiber scaffold is designed to address these concerns. In this prospective, single-blind trial, 60 patients were randomly allocated in a 1:1 ratio to treatment with a Mirage sirolimus-eluting bioresorbable microfiber scaffold or an Absorb bioresorbable vascular scaffold. The clinical endpoints were assessed at 30 days and at 6 and 12 months. In-device angiographic late loss at 12 months was quantified. Secondary optical coheren...Continue Reading

Citations

Feb 7, 2018·European Heart Journal·Vikas ThondapuPatrick W Serruys
Sep 19, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Chi-Hung HuangTing-Bin Yu
Jan 13, 2018·Korean Circulation Journal·Davide Capodanno
Jun 10, 2020·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Johannes Lammer
Aug 28, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Yuki KatagiriPatrick W Serruys
Dec 14, 2018·Nature Reviews. Cardiology·Hiroyuki JinnouchiAloke V Finn
Jul 10, 2020·Minerva cardioangiologica·Andrea BuonoAntonio Colombo
Mar 13, 2021·Advanced Functional Materials·Irsalan CockerillDonghui Zhu
Mar 20, 2021·Expert Review of Medical Devices·Xinlei WuYoshinobu Onuma
Jun 3, 2021·International Journal of Molecular Sciences·Dong-Ru HoChih-Shou Chen

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