PMID: 9449273Feb 4, 1998Paper

Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria

Antimicrobial Agents and Chemotherapy
M van VugtFrançois Nosten

Abstract

An open, randomized comparison of artemether-benflumetol (CGP 56 697; Novartis) with artesunate-mefloquine was conducted in 617 patients with acute uncomplicated multidrug-resistant falciparum malaria on the western border of Thailand. Both treatments rapidly and reliably cleared fever and parasitemia, and there was no significant difference in the initial therapeutic response parameters. Parasite genotyping was used to distinguish recrudescences from new infections. The 63-day cure rate for artesunate-mefloquine (94%) was significantly higher than the cure rate for artemether-benflumetol (81%) (P < 0.001). Both regimens were well tolerated. Nausea, vomiting, dizziness, sleep disorders, and other neurological side effects were between two and four times more common in the artesunate-mefloquine group than in the artemether-benflumetol group (P < 0.001). Artemether-benflumetol is effective and very well tolerated in the treatment of multidrug-resistant falciparum malaria. A higher dose than that used in the present study may improve efficacy.

References

Nov 1, 1992·The Journal of Antimicrobial Chemotherapy·N J White
Mar 1, 1985·The American Journal of Tropical Medicine and Hygiene·H K WebsterL W Pang
Sep 1, 1994·The American Journal of Tropical Medicine and Hygiene·T G BrewerB G Schuster
May 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·S PukrittayakameeN J White
Jun 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·S Looareesuwan
Sep 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·R N PriceN J White
Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·F O ter KuileN J White
Mar 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·C LuxemburgerF Nosten
Jul 1, 1997·Antimicrobial Agents and Chemotherapy·N J White
Jul 1, 1995·Parasitology Today·F P Mockenhaupt
Feb 1, 1989·Parasitology Today·D Strüchler

❮ Previous
Next ❯

Citations

Jan 2, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·M van VugtF Nosten
Jan 15, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·W Robert J Taylor, Nicholas J White
Apr 21, 2006·The Cochrane Database of Systematic Reviews·A A A OmariP Garner
Dec 14, 2006·Expert Opinion on Pharmacotherapy·Gilbert KokwaroAlexis Nzila
Jul 29, 2008·Tropical Medicine & International Health : TM & IH·Jacqueline L DeenArjen Dondorp
Dec 6, 2008·Malaria Journal·Kasia StepniewskaNicholas J White
Oct 29, 2013·The Cochrane Database of Systematic Reviews·Nithya GogtayDavid Sinclair
Jan 18, 2017·Antimicrobial Agents and Chemotherapy·Leah A Walker, David J Sullivan
May 4, 2017·The FEBS Journal·Reginald A KavisheMichael Alifrangis
Nov 4, 2000·Expert Opinion on Investigational Drugs·R N Price
May 3, 2000·British Journal of Clinical Pharmacology·P TanariyaW H Wernsdorfer
May 5, 2000·The Cochrane Database of Systematic Reviews·H M McIntosh, P Olliaro
Jan 31, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·R McGreadyF Nosten
Oct 27, 2004·Antimicrobial Agents and Chemotherapy·Kasia StepniewskaNicholas J White
Jan 17, 2004·Clinical Microbiology Reviews·Ambrose O TalisunaUmberto D'Alessandro
Feb 16, 2007·Tropical Medicine & International Health : TM & IH·Elizabeth A AshleyFrançois Nosten
Oct 13, 2006·Current Opinion in Infectious Diseases·S L Croft
Oct 20, 2005·The Cochrane Database of Systematic Reviews·A A A OmariP Garner
May 24, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Anayo Ogbonna, Chigozie J Uneke
Dec 29, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·R BakshiE Alteri
Aug 17, 1999·Tropical Doctor·M van Vugt, N J White
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·F EzzetN J White
Jul 21, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Poul-Erik KofoedLars Rombo
Dec 23, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·M van VugtN J White
May 26, 2006·British Journal of Clinical Pharmacology·Geoffrey Edwards, Giancarlo A Biagini
Jul 10, 2009·The Cochrane Database of Systematic Reviews·David SinclairPaul Garner
Apr 4, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andreas NeumayrChristoph Hatz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.