Randomized comparison of different ovarian stimulation regimens for assisted reproductive technology in baboons (Papio anubis)

Fertility and Sterility
Atunga NyachieoT M D'Hooghe

Abstract

To compare different methods of ovarian stimulation (OS) for assisted reproductive technology in baboons. Prospective randomized study. Institute of primate research. Baboons (n = 10) were randomized into two groups (of five animals each) during three different cycles to compare six protocols of OS. Cycle 1: clomiphene citrate (CC) alone (group CC) versus CC and GnRH agonist (group CC-Ag); cycle 2: recombinant gonadotropins (GON) without GnRH agonist (group GON) versus GON and depot GnRH agonist (group GON-AgDepo-1); cycle 3: GON and depot GnRH agonist (group GON-AgDepo-2) versus GON and daily GnRH agonist in a classic long protocol (group GON-Ag). Oocyte aspiration was performed 34-36 hours after injecting 5,000 IU rhCG, followed by fertilization via intracytoplasmic sperm injection (ICSI). Number and quality of oocytes retrieved and their fertilization rate. More metaphase II (MII) oocytes were retrieved using the GON-AgDepo-1 (n = 12; 64% MII), GON-AgDepo-2 (n = 9; 79% MII), GON-Ag (n = 16; 88% MII), and GON (n = 6; 59% MII) protocols compared with the CC (n = 9; 15% MII) and CC-Ag (n = 14; 20% MII) protocols. Fertilization by ICSI varied between 43% and 71%. In baboons, long and depot protocols yield similar numbers of MII ...Continue Reading

References

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Jun 19, 2004·Reproductive Biology and Endocrinology : RB&E·Barry D Bavister
Jun 24, 2005·Cloning and Stem Cells·Barry D BavisterCarol A Brenner
Oct 16, 2007·Gynecologic and Obstetric Investigation·Atunga NyachieoThomas M D'Hooghe
Nov 3, 2007·Journal of Medical Primatology·D ChaiT D'Hooghe
Oct 7, 2008·Animal Reproduction Science·Atunga NyachieoThomas M D'Hooghe

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Citations

Jan 11, 2013·Biology of Reproduction·Ov D Slayden
Dec 4, 2003·Reproductive Biology and Endocrinology : RB&E·Cleophas M KyamaThomas M D'Hooghe
Nov 23, 2006·Reproductive Biology and Endocrinology : RB&E·Julie M Hastings, Asgerally T Fazleabas
Jan 10, 2002·Environmental Health Perspectives·Linda S Birnbaum, Audrey M Cummings
Mar 16, 2012·Environmental Health Perspectives·Germaine M Buck LouisKurunthachalam Kannan

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