Randomized comparison of dry tablet insertion versus gel form of vaginal misoprostol for second trimester pregnancy termination

The Journal of Obstetrics and Gynaecology Research
S Pongsatha, T Tongsong

Abstract

To compare the effectiveness of vaginal misoprostol between dry tablet insertion and gel form for second trimester pregnancy termination. A non-blinded block randomized controlled trial was conducted on 148 pregnant women with live fetuses in the second trimester undergoing pregnancy termination. They were randomly allocated to receive vaginal misoprostol (400 microg) either dry tablet insertion (n=72) or gel form (n=76). The same dose was then repeated every 3 h if adequate uterine contraction was not achieved until 48 h after the initiation of misoprostol. If abortion did not occur within this period, the treatment was considered a failure and other technique of termination was then given based on the decision of the attending physicians and the cervical status. The mean induction-abortion interval in group 1 (20.9+/-12.3 h) was not significantly different from that in group 2 (17.7+/-10.2 h). The mean total dose of misoprostol was also not significantly different between the two groups (group 1, 1556.9 microg; group 2, 1350.9 microg), but the adverse effects of misoprostol (chill and diarrhoea) were more common in the gel group. Tablet insertion or gel form of vaginal misoprostol have similar effectiveness but the gel form w...Continue Reading

References

Dec 16, 1997·Obstetrics and Gynecology·S J CarlanW F O'Brien
Jun 8, 2002·Obstetrics and Gynecology·Luis Sanchez-RamosAndrew M Kaunitz
Feb 26, 2004·American Journal of Obstetrics and Gynecology·Jerry M GillesUNKNOWN National Institute of Child Health and Human Development Management of Early Pregnancy Failure Trial
Apr 22, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S KelekciK Savan
Oct 20, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S Pongsatha, T Tongsong

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Citations

Jan 13, 2010·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Bulent YilmazNuri Danisman
Jul 28, 2009·Contraception·Jayati Kusari Basu, Debashis Basu
Jun 14, 2012·The Journal of Obstetrics and Gynaecology Research·Saipin Pongsatha, Theera Tongsong
Aug 16, 2005·American Journal of Obstetrics and Gynecology·Rodney K Edwards, Shireen M Sims
Aug 6, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Roel De HeusBen W J Mol
Jan 21, 2011·The Cochrane Database of Systematic Reviews·Hajo WildschutNathalie Kapp

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